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    Analgesic compositions
    2.
    发明公开
    Analgesic compositions 失效
    分析师Zusammensetzungen。

    公开(公告)号：EP0499399A1

    公开(公告)日：1992-08-19

    申请号：EP92300987.2

    申请日：1992-02-06

    申请人： AMERICAN HOME PRODUCTS CORPORATION

    发明人： Mody, Dhiraj Shantilal ,  Blank, Robert George ,  Agasim, Gary Robert ,  Chen, Gloria Yoshiko

    IPC分类号： A61K31/19 ,  A61K47/00 ,  A61K9/107

    CPC分类号： A61K9/0014 ,  A61K31/19 ,  Y10S514/871 ,  Y10S514/887 ,  Y10S514/939 ,  Y10S514/969

    摘要： The invention provides a topical analgesic composition comprising an oil-in-water emulsion containing about 5% to about 12% by weight of ibuprofen and about 60% to about 90% by weight of water, the oil phase of the emulsion consisting essentially of emollient constituents that do not dissolve the ibuprofen to any great extent at a pH of 4-7, the composition having a pH of about 4 to about 7.2 such that the ibuprofen is suspended in substantially solid crystalline form and the ibuprofen which is dissolved is partially in the neutral or non-charged state. The invention also includes a process for preparing this composition.

    摘要翻译： 本发明提供了一种局部镇痛组合物，其包含含约5％至约12％重量的布洛芬和约60％至约90％重量的水的水包油乳液，所述乳液的油相基本上由润肤剂 在4-7的pH下不会很大程度地溶解布洛芬的组分，该组合物具有约4至约7.2的pH，使得布洛芬悬浮在基本上固态的结晶形式中，并且溶解的布洛芬部分地 中性或非充电状态。 本发明还包括制备该组合物的方法。