公开(公告)号：EP1664053A1

公开(公告)日：2006-06-07

申请号：EP04783482.5

申请日：2004-08-23

申请人： AMGEN INC.

发明人： NUNES, Joseph J. ,  ZHU, Xiaotian ,  ERMANN, Monika ,  GHIRON, Chiara ,  JOHNSTON, David N. ,  SALUSTE, Carl-Gustaf Pierre

IPC分类号： C07D487/14 ,  A61K31/519

CPC分类号： C07D487/14

摘要： The present invention relates to tetracyclic pyrimidines or pyridines or pharmaceutically-acceptable salts or derivatives thereof. Also included are methods of use of the tetracyclic pyrimidines or pyridines including use related to treating inflammation, inhibiting T cell activation and proliferation, arthritis, organ transplant, ischemic or reperfusion injury, myocardial infarction, stroke, multiple sclerosis, inflammatory bowel disease and many other related disorders in a subject, the methods comprising administering a therapeutically-effective amount a compound as described above to the subject.

摘要翻译： 本发明涉及四环嘧啶或吡啶或其药学上可接受的盐或衍生物。 还包括使用四环嘧啶或吡啶的方法，包括与治疗炎症，抑制T细胞活化和增殖，关节炎，器官移植，局部缺血或再灌注损伤，心肌梗塞，中风，多发性硬化症，炎症性肠病等有关的用途 所述方法包括向所述受试者施用治疗有效量的如上所述的化合物。

公开(公告)号：EP1664053B1

公开(公告)日：2007-01-24

申请号：EP04783482.5

申请日：2004-08-23

申请人： AMGEN INC.

发明人： NUNES, Joseph J. ,  ZHU, Xiaotian ,  ERMANN, Monika ,  GHIRON, Chiara ,  JOHNSTON, David N. ,  SALUSTE, Carl-Gustaf Pierre

IPC分类号： C07D487/14 ,  A61K31/519

CPC分类号： C07D487/14

摘要： The present invention relates to tetracyclic pyrimidines or pyridines or pharmaceutically-acceptable salts or derivatives thereof. Also included are methods of use of the tetracyclic pyrimidines or pyridines including use related to treating inflammation, inhibiting T cell activation and proliferation, arthritis, organ transplant, ischemic or reperfusion injury, myocardial infarction, stroke, multiple sclerosis, inflammatory bowel disease and many other related disorders in a subject, the methods comprising administering a therapeutically-effective amount a compound as described above to the subject.