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公开(公告)号：EP3737694A1
公开(公告)日：2020-11-18
申请号：EP19703451.5
申请日：2019-01-11
申请人： Amgen Inc.
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公开(公告)号：EP3689371A1
公开(公告)日：2020-08-05
申请号：EP20158997.5
申请日：2014-03-12
申请人： Amgen Inc.
IPC分类号： A61K39/00 , A61K39/395 , A61P19/02 , A61P29/00 , A61P29/02 , A61P37/06 , C07K14/00 , C07K16/28
摘要： Described herein are bispecific proteins specific for BAFF and B7RP1, nucleic acids encoding such proteins, methods of making such proteins, and uses for such proteins.
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4.发明授权
公开(公告)号：EP2718323B1
公开(公告)日：2018-07-25
申请号：EP12727726.7
申请日：2012-06-05
申请人： Amgen Inc.
发明人： LI, Yang , STEVENS, Jennitte , KING, Chadwick, Terence , FOLTZ, Ian , KANNAN, Gunasekaran , YIE, Junming , HU, Shaw-Fen, Sylvia
CPC分类号： C07K16/2863 , A61K2039/505 , C07K14/71 , C07K16/40 , C07K2317/21 , C07K2317/31 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/75 , C07K2319/00 , C07K2319/30 , C12Y302/01031
摘要： The present invention provides compositions and methods relating to or derived from antigen binding proteins capable of inducing B-Klotho, and or FGF21-like mediated signaling.
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5.发明公开HUMAN ANTIGEN BINDING PROTEINS THAT BIND TO A COMPLEX COMPRISING BETA-KLOTHO AND AN FGF RECEPTOR 有权EINEN KOMPLEX AUS BETA-KLOTHO UND EINEM FGFR1c BINDENDE MENSCHLICHE ANTIGENBINDENDE PROTEINE
公开(公告)号：EP2718323A2
公开(公告)日：2014-04-16
申请号：EP12727726.7
申请日：2012-06-05
申请人： Amgen Inc.
发明人： LI, Yang , STEVENS, Jennitte , KING, Chadwick, Terence , FOLTZ, Ian , KANNAN, Gunasekaran , YIE, Junming , HU, Shaw-Fen, Sylvia
IPC分类号： C07K16/28
CPC分类号： C07K16/2863 , A61K2039/505 , C07K14/71 , C07K16/40 , C07K2317/21 , C07K2317/31 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/75 , C07K2319/00 , C07K2319/30 , C12Y302/01031
摘要： The present invention provides compositions and methods relating to or derived from antigen binding proteins capable of inducing B-Klotho, and or FGF21-like mediated signaling.
摘要翻译： 本发明提供与能够诱导B-Klotho和/或FGF21样介导的信号传导的抗原结合蛋白相关或衍生的组合物和方法。
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公开(公告)号：EP4029877A1
公开(公告)日：2022-07-20
申请号：EP21217086.4
申请日：2018-08-03
申请人： Amgen, Inc
发明人： ALI, Khaled, M.K.Z. , AGRAWAL, Neeraj, Jagdish , KANNAN, Gunasekaran , FOLTZ, Ian , WANG, Zhulun , BATES, Daren , MOCK, Marissa , TAKENAKA, Shunseke
摘要： Provided herein are IL-21 muteins and fusion proteins comprising the same for use in methods of treating a disease. Related conjugates, nucleic acids, vectors, host cells, pharmaceutical compositions and kits are also provided herein. Methods of making the IL-21 muteins and fusion proteins comprising the same, as well as methods of treating a subject in need thereof, are provided by the present disclosure. Further provided are PD-1 antigen-binding proteins.
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公开(公告)号：EP2928922B1
公开(公告)日：2020-09-23
申请号：EP13811711.4
申请日：2013-12-05
申请人： Amgen Inc.
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8.发明授权
公开(公告)号：EP3061770B8
公开(公告)日：2020-02-12
申请号：EP15187984.8
申请日：2009-01-06
申请人： Amgen Inc.
IPC分类号： C07K16/46
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公开(公告)号：EP2970441B1
公开(公告)日：2019-03-06
申请号：EP14769541.5
申请日：2014-03-14
申请人： Amgen Inc.
发明人： KANNAN, Gunasekaran
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公开(公告)号：EP3027647A2
公开(公告)日：2016-06-08
申请号：EP14832297.7
申请日：2014-07-30
申请人： Amgen Inc.
IPC分类号： C07K16/00
CPC分类号： A61K38/18 , A61K47/48376 , A61K47/6801 , C07K14/475 , C07K16/00 , C07K2317/52 , C07K2317/526 , C07K2319/30
摘要： This disclosure provides polypeptides comprising an antibody Fc region having a deletion of one or more cysteine residues in the hinge region and substitution with a sulfhydryl-containing residue of one or more CH3-inteface amino acids. Also, provided are Fc-fusion proteins and antibodies containing said polypeptides, nucleic acids and vectors encoding said polypeptides, along with host cells and methods for making said polypeptides.
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