公开(公告)号：EP1546715A4

公开(公告)日：2007-01-10

申请号：EP03728479

申请日：2003-04-23

申请人： ANALYTICAL BIOLOG SERVICES INC

发明人： REPPY MARY A ,  SALLER CHARLES F

IPC分类号： G01N33/53 ,  G01N20060101 ,  G01N33/542 ,  G01N33/544

CPC分类号： G01N33/544 ,  G01N33/542

摘要： Two-dimensional and/or three-dimensional polymeric or extended solid arrays, such as arrays of a polydiacetylene backbone, are used to evaluate the organic/water partition coefficient and/or oral absorptivity and/or transcellular permeability of a compound by monitoring the change in the fluorescence or phosphorescence of the array upon exposure to the compound and comparing it to a known change in fluorescence or phosphorescence, respectively. The method can also be used to evaluate the ability of a compound to bind to a protein.

公开(公告)号：EP1792163A4

公开(公告)日：2008-08-27

申请号：EP05784910

申请日：2005-08-08

申请人： ANALYTICAL BIOLOG SERVICES INC

发明人： REPPY MARY A ,  SALLER CHARLES F

IPC分类号： G01N21/00 ,  G01N21/76 ,  G01N21/77

CPC分类号： G01N33/54306 ,  G01N33/52 ,  G01N33/521 ,  G01N33/532 ,  G01N33/533 ,  G01N33/5432 ,  G01N33/54373 ,  G01N33/544 ,  G01N33/582

摘要： Two-dimensional and/or three-dimensional polymeric or extended solid arrays, such as arrays of a polydiacetylene backbone, are used to screen a plurality of samples containing different species by monitoring the change in the fluorescence or phosphorescence of the array upon exposure to the sample and comparing it to a known change in fluorescence or phosphorescence, respectively.

公开(公告)号：EP1907563A4

公开(公告)日：2009-04-22

申请号：EP06788671

申请日：2006-07-28

申请人： ANALYTICAL BIOLOG SERVICES INC

发明人： REPPY MARY A ,  SALLER CHARLES F

IPC分类号： G01N33/53 ,  G01N33/52 ,  G01N33/543

CPC分类号： G01N33/558 ,  G01N33/5432 ,  G01N33/544 ,  G01N33/582 ,  G01N2500/00

摘要： Two-dimensional and/or three-dimensional polymeric or extended solid arrays comprising a polydiacetylene backbone, are used to evaluate the organic/water partition coefficient and/or oral absorptivity and/or ability of a compound to diffuse into cell membranes and/or transcellular permeability properties of a compound and/or the ionization state of a compound and/or the volume of distribution of a compound and/or the distribution of a compound into different tissues and/or the partitioning of a compound into cell organelles by monitoring the change in the fluorescence or phosphorescence upon exposure to the compound and optionally comparing it to a known change in fluorescence or phosphorescence, respectively. The method can also be used to evaluate the ability of a compound to bind to a protein.

公开(公告)号：EP1279023A4

公开(公告)日：2004-09-29

申请号：EP01924210

申请日：2001-03-20

申请人： ANALYTICAL BIOLOG SERVICES INC

发明人： REPPY MARY A ,  SPORN SARAH A ,  SALLER CHARLES F

IPC分类号： C12Q1/44 ,  G01N21/05 ,  G01N21/64 ,  G01N21/78 ,  G01N33/533 ,  G01N33/543 ,  G01N33/544 ,  G01N33/58 ,  G01N21/00 ,  C07H21/04 ,  C12M1/00 ,  C12N1/00 ,  C12N1/20 ,  C12N11/00 ,  C12Q1/68 ,  G01N21/01 ,  G01N21/17 ,  G01N31/20 ,  G01N33/53 ,  G01N33/537 ,  G01N33/538 ,  G01N33/546 ,  G01N33/552 ,  G01N33/567

CPC分类号： G01N33/544 ,  G01N21/6428 ,  G01N33/5432 ,  G01N33/582 ,  Y10S436/829

摘要： Two-dimensional and three-dimensional arrays of a polydiacetylene backbone having a substrate incorporated are used in chemical sensing methods to detect the interaction of an analyte with the substrate by monitoring the change in the fluorescence of the array.