公开(公告)号：EP1162951A1

公开(公告)日：2001-12-19

申请号：EP00908780.0

申请日：2000-02-24

申请人： ANDRX PHARMACEUTICALS, INC.

发明人： CHEN, Chih-Ming ,  XIE, Jianbo ,  JAN, Steve

IPC分类号： A61K9/14 ,  A61K9/52 ,  A61K9/58

CPC分类号： A61K9/2081 ,  A61K9/5078 ,  A61K9/5084

摘要： A controlled release dosage form of bupropion hydrochloride which comprises: (a) a first pellet having a core of bupropion hydrochloride and hydroxypropyl methylcellulose at a weight ratio of 10:1 to 30:1 and a coating of a mixture of an acrylic resin which is soluble in acidic media and ethyl cellulose; (b) a second pellet having a core of bupropion hydrochloride and hydroxypropyl methylcellulose at a ratio of 10:1 to 30:1; an inner coating of a mixture of an acrylic resin which is soluble in acidic media and a water insoluble polymer and an outer coating which comprises an enteric coating polymer.

公开(公告)号：EP1124543A1

公开(公告)日：2001-08-22

申请号：EP99957493.2

申请日：1999-11-01

申请人： ANDRX PHARMACEUTICALS, INC.

发明人： CHEN, Chih-Ming ,  CHENG, Xiu, Xiu

IPC分类号： A61K9/58 ,  A61K9/60 ,  A61K9/62

CPC分类号： A61K9/5078 ,  A61K9/5026 ,  A61K9/5084 ,  A61K31/554 ,  Y10S514/97

摘要： A once-a-day controlled release diltiazem formulation comprises: (a) 20-50 wt.% of enteric polymeric membrane coated pellets comprising a polymer membrane coated core which comprises a biologically inert core which is coated with a first layer consisting essentially of diltiazem and polymeric binder; and a second layer which comprises a membrane comprising a pH dependent polymeric material; and (b) 50-80 wt.% of delayed pulse polymeric membrane coated pellets comprising a polymeric membrane coated core comprising a biologically inert core which is coated with a first layer which consists essentially of diltaziem and a polymeric binder and a second layer which comprises a polymeric membrane and a akaline a alkaline earth metal stearate which will substantially maintain its integrity in the varying pH conditions of the gastrointestinal tract but is permeable to diltiazem, and (c) a unit dose containment system.

公开(公告)号：EP1107763B1

公开(公告)日：2004-06-23

申请号：EP99945371.5

申请日：1999-08-31

申请人： ANDRX PHARMACEUTICALS, INC.

发明人： CHEN, Chih-Ming ,  CHENG, Xiu, Xiu ,  CHOU, Joseph ,  JAN, Steve

IPC分类号： A61K31/64 ,  A61K9/28 ,  A61P3/10

CPC分类号： A61K9/2886 ,  A61K9/0004 ,  A61K9/2013 ,  A61K9/2031 ,  A61K9/2054 ,  A61K9/282 ,  A61K9/2866 ,  A61K31/64 ,  A61K31/155 ,  A61K2300/00

摘要： A controlled release pharmaceutical tablet containing antihyperglycemic drug and a hypoglycemic drug that does not contain an expanding or gelling polymer layer and comprising a core containing the antihyperglycemic drug and the hypoglycemic drug, a semipermeable coating membrane surrounding the core and at least one passageway in the membrane to allow the drugs to be released from the core.

摘要翻译： 一种控释药物片剂含抗高血糖药物和降血糖药确实不包含，扩大或胶凝聚合物层和包含芯含有的抗高血糖药物和降血糖药，周围在膜中的芯和至少一个通道的半透包衣膜 允许药物从核心释放。

公开(公告)号：EP0744942B1

公开(公告)日：2002-07-24

申请号：EP95908570.5

申请日：1995-01-18

申请人： ANDRX PHARMACEUTICALS, INC.

发明人： CHEN, Chih-Ming ,  CHIAO, Charles S.L.

IPC分类号： A61K9/22 ,  A61K9/26 ,  A61K9/20

CPC分类号： A61K9/2054 ,  A61K9/2009

摘要： The invention is directed to a method for the modification of the rate of release of a drug from a hydrogel which is based on the use of an effective amount of a pharmaceutically acceptable ionizable compound that is capable of providing a substantially zero-order release rate of drug from the hydrogel.

公开(公告)号：EP0822809A1

公开(公告)日：1998-02-11

申请号：EP96908796.0

申请日：1996-03-13

申请人： ANDRX PHARMACEUTICALS, INC.

发明人： CHEN, Chih-Ming ,  LEE, Der-Yang

IPC分类号： A61K9 ,  A61K31

CPC分类号： A61K9/209 ,  A61K9/0004 ,  A61K9/1652 ,  A61K9/5047 ,  A61K31/137 ,  Y10S514/853 ,  Y10S514/96

摘要： A controlled release pharmaceutical tablet is disclosed which is based on: (a) a compressed core which contains: i) a medicament; ii) from 5 to 20 % by weight of a water soluble osmotic agent based on the total weight of the compressed core; iii) a water soluble pharmaceutically acceptable polymeric binder; iv) a conventional pharmaceutical excipient; and (b) a dual layer membrane coating around said core which consists essentially of: i) a first inner coating layer for sustained release of the medicament, said inner coating layer consisting essentially of a plasticized water insoluble pharmaceutically acceptable polymer and a pharmaceutically acceptable water soluble polymer, and; ii) a second outer coating layer for immediate release of a medicament, said outer coating layer consisting essentially of an effective amount of a medicament and a water soluble polymer. The controlled release formulation is suitable for the once-a-day administration of medicaments.

公开(公告)号：EP0822809B1

公开(公告)日：2006-06-07

申请号：EP96908796.4

申请日：1996-03-13

申请人： ANDRX PHARMACEUTICALS, INC.

发明人： CHEN, Chih-Ming ,  LEE, Der-Yang

IPC分类号： A61K9/22 ,  A61K9/36

CPC分类号： A61K9/209 ,  A61K9/0004 ,  A61K9/1652 ,  A61K9/5047 ,  A61K31/137 ,  Y10S514/853 ,  Y10S514/96

摘要： A controlled release pharmaceutical tablet is disclosed which is based on: (a) a compressed core which contains: i) a medicament; ii) from 5 to 20 % by weight of a water soluble osmotic agent based on the total weight of the compressed core; iii) a water soluble pharmaceutically acceptable polymeric binder; iv) a conventional pharmaceutical excipient; and (b) a dual layer membrane coating around said core which consists essentially of: i) a first inner coating layer for sustained release of the medicament, said inner coating layer consisting essentially of a plasticized water insoluble pharmaceutically acceptable polymer and a pharmaceutically acceptable water soluble polymer, and; ii) a second outer coating layer for immediate release of a medicament, said outer coating layer consisting essentially of an effective amount of a medicament and a water soluble polymer. The controlled release formulation is suitable for the once-a-day administration of medicaments.

公开(公告)号：EP0835102B1

公开(公告)日：2005-01-19

申请号：EP96918078.5

申请日：1996-06-05

申请人： ANDRX PHARMACEUTICALS, INC.

发明人： CHEN, Chih-Ming ,  LEE, Der-Yang ,  XIE, Jianbo ,  RODRIGUEZ, Aurelio

IPC分类号： A61K9/36

CPC分类号： A61K9/0004

摘要： A controlled release pharmaceutical tablet having at least one passageway, said tablet having: (a) a compressed core which comprises: (i) a medicament; (ii) an amount of a water soluble osmotic agent which is effective to cause the medicament to be delivered from said passageway in the presence of aqueous media; (iii) a water-swellable pharmaceutically acceptable polymer; and (b) a membrane coating around said core tablet which comprises a water insoluble pharmaceutically acceptable polymer.

公开(公告)号：EP0814780B1

公开(公告)日：2003-10-01

申请号：EP96910439.7

申请日：1996-03-13

申请人： ANDRX PHARMACEUTICALS, INC.

发明人： CHEN, Chih-Ming

IPC分类号： A61K9/16 ,  A61K9/58 ,  A61K9/62 ,  A61K31/55 ,  A61K9/50

CPC分类号： A61K9/5084 ,  A61K9/5078 ,  A61K31/554 ,  Y10S514/963

摘要： A once-a-day controlled release diltiazem formulation is described which includes: (a) from 20 to 50 % by weight of enteric polymeric membrane coated pellets comprising a polymer membrane coated core which comprises a biologically inert core which is coated with a first layer which consists essentially of diltiazem and a polymeric binder; and a second layer which comprises a membrane comprising a pH dependent polymeric material; and (b) from 50 % to 80 % by weight of delayed pulse polymeric membrane coated pellets comprising a polymeric membrane coated core which comprises a biologically inert core which is coated with a first layer which consists essentially of diltiazem and a polymeric binder and a second layer which comprises a polymeric membrane which will substantially maintain its integrity in the varying pH conditions of the gastrointestinal tract but is permeable to diltiazem; and (c) a unit dose containment system.

公开(公告)号：EP1063971A1

公开(公告)日：2001-01-03

申请号：EP99912705.3

申请日：1999-03-19

申请人： ANDRX PHARMACEUTICALS, INC.

发明人： CHENG, Xiu, Xiu ,  CHEN, Chih-Ming ,  JAN, Steve ,  CHOU, Joseph

IPC分类号： A61K9/20

CPC分类号： A61K9/2866 ,  A61K9/0004 ,  A61K9/2072 ,  A61K9/282 ,  A61K9/2886 ,  A61K31/155

摘要： A controlled release antihyperglycemic tablet that does not contain an expanding polymer and comprising a core containing the antihyperglycemic drug, a semipermeable membrane coating the core and at least one passageway in the membrane.

公开(公告)号：EP1035842B1

公开(公告)日：2005-10-26

申请号：EP98960752.8

申请日：1998-12-04

申请人： ANDRX PHARMACEUTICALS, INC.

发明人： CHEN, Chih-Ming ,  CHOU, Joseph ,  WONG, David

IPC分类号： A61K9/28 ,  A61K9/20 ,  A61K31/22

CPC分类号： A61K31/366 ,  A61K9/0004 ,  A61K9/2018 ,  A61K9/2031 ,  A61K9/2886 ,  A61K31/22

摘要： A controlled release dosage formulation is described which is based on a combination of: (a) a compressed tablet core which contains an alkyl ester of a hydroxy substituted naphthalene derivative, a pharmaceutically acceptable, water swellable polymer and an osmotic agent; and (b) an outer coating layer which completely covers the osmotic core and comprises a pH sensitive coating agent and a water insoluble polymer.