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1.发明授权THE USE OF CYTOKINE ABLE TO BIND IL-18BP AND OF INHIBITING THE ACTIVITY OF A SECOND CYTOKINE 有权细胞因子IL-18BP的使用装订和第二细胞因子INHIBIT的效果可
公开(公告)号：EP1572291B1
公开(公告)日：2013-04-03
申请号：EP03756906.8
申请日：2003-10-03
申请人： ARES TRADING S.A.
CPC分类号： A61K38/2006 , A61K38/1793 , C07K16/245 , C12N15/1136 , C12N2310/11 , C12N2310/14
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公开(公告)号：EP1392830B1
公开(公告)日：2006-01-11
申请号：EP02758668.4
申请日：2002-03-08
申请人： ARES TRADING S.A.
发明人： DINARELLO, Charles , KIM, Soo-Hyun
摘要： The invention provides mutants of IL-18 with lower affinity to IL-18BP than the wild type IL-18 molecule.
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公开(公告)号：EP1392830A2
公开(公告)日：2004-03-03
申请号：EP02758668.4
申请日：2002-03-08
申请人： ARES TRADING S.A.
发明人： DINARELLO, Charles , KIM, Soo-Hyun
摘要： The invention provides mutants of IL-18 with lower affinity to IL-18BP than the wild type IL-18 molecule.
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4.发明公开THE USE OF CYTOKINE ABLE TO BIND IL-18BP AND OF INHIBITING THE ACTIVITY OF A SECOND CYTOKINE 有权细胞因子IL-18BP的使用装订和第二细胞因子INHIBIT的效果可
公开(公告)号：EP1572291A2
公开(公告)日：2005-09-14
申请号：EP03756906.8
申请日：2003-10-03
申请人： ARES TRADING S.A.
IPC分类号： A61N1/00
CPC分类号： A61K38/2006 , A61K38/1793 , C07K16/245 , C12N15/1136 , C12N2310/11 , C12N2310/14
摘要： The present invention relates to the use of a cytokine-1, preferably from the IL-1 family more preferably IL-1F7b, or an isoform, mutein, fused protein, functional derivative or fragment thereof, capable of binding to IL-18 BP or a mutein, fused protein, functional derivative or fragment thereof and capable of inhibiting a receptor of a cytokine-2, cytokine-2 being a member of the IL-1 family, preferably IL-18, in the manufacture of a medicament for the treatment or prevention of a disease which is caused or aggravated by inducing said receptor of cytokine-2.
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