专利检索 ap:("ARIAD GENE THERAPEUTICS INC") AND inv:"BRUGGE JOAN S" 第 1 页

1.

发明公开
REGULATABLE ELIMINATION OF GENE EXPRESSION, GENE PRODUCT FUNCTION AND ENGINEERED HOST CELLS 失效
标题翻译：基因表达可调消除和基因产品的功能基因改造的宿主细胞

公开(公告)号：EP0776335A4

公开(公告)日：1999-09-15

申请号：EP95930868

申请日：1995-08-18

申请人： ARIAD GENE THERAPEUTICS INC

发明人： BRUGGE JOAN S , CRABTREE GERALD R

IPC分类号： A01K67/027 , A61K48/00 , C07K7/64 , C07K14/715 , C07K14/725 , C07K19/00 , C12N5/10 , C12N15/09 , C12N15/63 , C12P17/18 , C07K14/00 , C07H21/00 , C12N5/00 , C12N15/00

CPC分类号： A61K48/00 , A01K2217/05 , C07K7/645 , C07K14/7051 , C07K14/715 , C07K2319/00 , C07K2319/03 , C07K2319/035 , C07K2319/09 , C07K2319/20 , C07K2319/42 , C07K2319/43 , C07K2319/71 , C07K2319/715 , C07K2319/81 , C07K2319/90 , C12N15/63 , C12P17/188

摘要： Materials and methods are disclosed for regulated obstruction of the expression of a target gene or the biological effect of its gene product in genetically engineered cells or organisms containing them. Aspects of the invention are exemplified by recombinant modifications of host cells and their use in vitro and in vivo for the regulatable blockade of expression of a target gene, for interference with the function or effect of a target gene product or for the regulatable elimination of a target gene.