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    Method of immunological assaying of human osteocalcin, reagent and kit therefor, antibody to human osteocalcin, hybridoma producing said antibody, and method of producing it
    4.
    发明公开
    Method of immunological assaying of human osteocalcin, reagent and kit therefor, antibody to human osteocalcin, hybridoma producing said antibody, and method of producing it 失效
    一种用于免疫学Nachweiss人类Osleokalzin，试剂和检测试剂盒为抗体对人骨钙素的方法，杂交瘤产生祖阿曼用于生产它们的这些抗体和方法。

    公开(公告)号：EP0646794A1

    公开(公告)日：1995-04-05

    申请号：EP94113194.8

    申请日：1990-02-08

    申请人： TEIJIN LIMITED

    发明人： Hosoda, Kenji ,  Honda, Hitomi ,  Kubota, Takaharu ,  Masuho, Yasuhiko

    IPC分类号： G01N33/82 ,  G01N33/74 ,  G01N33/68 ,  G01N33/577 ,  G01N33/543 ,  C12P21/08 ,  A61K39/395 ,  C07K1/04

    CPC分类号： G01N33/6887 ,  C07K14/78 ,  C07K16/18

    摘要： A method of immunologically assaying intact human osteocalcin in a human assay sample by using an antibody having an epitope in a region of an amino acid sequence 1 to 20 on the N-termianl side of human osteocalcinand an antibody having an epitope in a region of an amino acid sequence 36 to 49 on the C-terminal side of human osteocalcin. A reagent and a kit therefor. Furthermore, a method of immunologicaslly assaying the total amount of human intact osteocalcin and a reagent thereof in a human assay sample. A reagent and a kit therefor. A monclonal antibody and a polyclonal antibody used for the assay. A process for producing these antibodies, and utilization of these antibodies.

    摘要翻译： 的通过在氨基酸序列1的区域中使用在抗体具有抗原表位上的表位具有对抗体的人类osteocalcinand的N吡嗪酰胺侧的区域免疫测定人测定样品中的完整的人骨钙素至20所述的方法 氨基酸序列36〜49对人体骨钙素的C末端侧。 的试剂和用于其的试剂盒。 进一步，测定immunologicaslly的人完整骨钙素的总量和人测定样品在它们的试剂的方法。 的试剂和用于其的试剂盒。 甲单株抗体和用于测定的多克隆抗体。 一种用于生产合成抗体的方法，和合成抗体的利用率。

    Antitumor protein hybrid and process for the preparation thereof
    6.
    发明公开
    Antitumor protein hybrid and process for the preparation thereof 失效
    抗肿瘤化杂合蛋白及其制备方法。

    公开(公告)号：EP0023401A2

    公开(公告)日：1981-02-04

    申请号：EP80302357.1

    申请日：1980-07-11

    申请人： TEIJIN LIMITED

    发明人： Masuho, Yasuhiko ,  Hara, Takeshi

    IPC分类号： A61K39/395 ,  A61K37/02 ,  C07G7/00

    CPC分类号： A61K47/6827 ,  A61K47/6889 ,  Y10S530/866

    摘要： Antitumor protein hybrid, composed of a moiety which is substantially the fragment Fab of an antitumor immunogloblin and a moiety which is the subunit A of ricin, which is expressed bythe following formula (1):
    (where Fab indicates a moiety which is substantially the fragment Fab of an antitumor immunogloblin; RA indicates a moiety which is the subunit A of ricin; X indicates a divalent organic radical; S, and S 2 are both sulfur atoms, S 1 indicating a sulfur atom arising from the disulfide bond (-S-S- bond) in an immunoglobulin and S 2 a sulfur atom arising from the disulfide bond in ricin; n stands for 0 or 1 and m stands for an integer of 1 to 5). This antitumor protein hybrid has remarkable and specific cytotoxicity against tumor cells.