公开(公告)号：EP2013218A2

公开(公告)日：2009-01-14

申请号：EP07755575.3

申请日：2007-04-16

申请人： ARQULE, INC.

发明人： LAPIERRE, Jean-Marc ,  NAMDEV, Nivedita D. ,  ASHWELL, Mark A. ,  FRANCE, Dennis S. ,  WU, Hui ,  HUTCHINS, Patrick M. ,  TANDON, Manish ,  LIU, Yanbin ,  LINK, Jeff S. ,  ALI, Syed M. ,  BRASSARD, Chris J. ,  NICEWONGER, Robb B. ,  FILIKOV, Anton ,  CARAZZA, Rebecca J.

IPC分类号： C07D498/04 ,  C07D513/04 ,  A61K31/429 ,  A61K31/4188 ,  A61K31/35

CPC分类号： C07D513/04

摘要： The present invention provides imidazooxazole and imidazothiazole compounds and their synthesis. The compounds of the present invention are capable of inhibiting the activity of RAF kinase, such as B-RAFV600E. The compounds are useful for the treatment of cell proliferative disorders such as cancer.