公开(公告)号：EP3196200A4

公开(公告)日：2018-02-28

申请号：EP15836701

申请日：2015-08-25

申请人： ASTELLAS PHARMA INC

发明人： TAKAHASHI TAISUKE ,  TANAKA HIROAKI ,  AKAIWA MICHINORI ,  NEGORO KENJI ,  MIHARA HISASHI ,  FUJI HIDEYOSHI ,  TAKAMATSU HAJIME

IPC分类号： C07D417/14 ,  A61K31/4439 ,  A61K31/496 ,  A61K31/506 ,  A61P13/02 ,  A61P13/10 ,  A61P43/00 ,  C07D417/12

CPC分类号： A61K31/496 ,  A61K31/4439 ,  A61K31/506 ,  C07D417/12 ,  C07D417/14

摘要： [Problem] To provide a compound useful as an active ingredient in a pharmaceutical composition for treating bladder storage disorders, dysuria, lower urinary tract diseases, and the like. [Solution] The inventors of the present invention have discovered that a 2-aminothiazole derivative exhibits an excellent muscarinic M 3 receptor positive allosteric modulator activity, and has potential as a preventative or therapeutic agent against bladder and urinary tract diseases to which bladder contraction mediated by muscarinic M 3 receptors contributes. The 2-aminothiazole derivative or salt thereof has potential as a preventative or therapeutic agent against bladder and urinary tract diseases such as, for example, dysuria including underactive bladder, and to which bladder contraction mediated by muscarinic M 3 receptors contributes.