公开(公告)号：EP2975023A4

公开(公告)日：2016-08-03

申请号：EP14763790

申请日：2014-03-13

申请人： ASTELLAS PHARMA INC

发明人： FUJIYASU JIRO ,  ASANO TORU ,  YAMAKI SUSUMU ,  KANEKO OSAMU ,  KOIKE YUKA ,  IMAIZUMI TOMOYOSHI ,  URANO YASUHARU ,  SATOU TOMOHKI ,  SASAMURA SATOSHI

IPC分类号： C07D333/40 ,  A61K31/24 ,  A61K31/343 ,  A61K31/381 ,  A61K31/472 ,  A61P13/12 ,  C07C279/18 ,  C07D217/26 ,  C07D307/81 ,  C07D333/24 ,  C07D333/68 ,  C07D333/70

CPC分类号： C07D333/70 ,  A61K31/24 ,  A61K31/343 ,  A61K31/381 ,  A61K31/472 ,  C07C279/18 ,  C07C2602/08 ,  C07C2602/10 ,  C07D217/26 ,  C07D307/81 ,  C07D333/24 ,  C07D333/40 ,  C07D333/68

摘要： [Problem] To provide a compound which is useful as an agent for preventing and/or treating kidney diseases. [Means for Solution] The present inventors have studied compounds having a trypsin inhibitory activity, and have confirmed that a guanidinobenzoic acid ester compound has a trypsin inhibitory activity, thereby completing the present invention. The guanidinobenzoic acid ester compound of the present invention can be used as an agent for preventing and/or treating kidney diseases (for example, chronic kidney disease, acute glomerulonephritis, acute kidney injury, and the like) as an agent which will substitute low-protein diet therapy, and/or as an agent for preventing and/or treating trypsin-related diseases (for example, chronic pancreatitis, gastroesophageal reflux disease, hepatic encephalopathy, influenza, and the like).

公开(公告)号：EP2757093A4

公开(公告)日：2015-02-25

申请号：EP12831685

申请日：2012-09-14

申请人： ASTELLAS PHARMA INC

发明人： FUJIYASU JIRO ,  OHNE KAZUHIKO ,  YAMAKI SUSUMU ,  IMAIZUMI TOMOYOSHI ,  HONDO TAKESHI ,  MATSUURA KEISUKE ,  SATOU TOMOHKI ,  SASAMURA SATOSHI

IPC分类号： C07C279/18 ,  A61K31/155 ,  A61K31/404 ,  A61P13/12 ,  A61P43/00 ,  C07C307/10 ,  C07D207/16 ,  C07D209/20 ,  C07D209/42 ,  C07D211/62 ,  C07D213/79 ,  C07D215/20 ,  C07D215/48 ,  C07D215/50 ,  C07D233/64 ,  C07D257/04 ,  C07D271/06 ,  C07D277/20 ,  C07D277/56 ,  C07D295/12 ,  C07D333/38

CPC分类号： C07C279/18 ,  C07B2200/07 ,  C07C2601/02 ,  C07C2601/14 ,  C07D207/16 ,  C07D209/20 ,  C07D209/42 ,  C07D211/62 ,  C07D213/79 ,  C07D215/20 ,  C07D215/48 ,  C07D215/50 ,  C07D217/26 ,  C07D233/64 ,  C07D257/04 ,  C07D271/06 ,  C07D271/07 ,  C07D277/20 ,  C07D277/56 ,  C07D295/12 ,  C07D295/13 ,  C07D333/38 ,  C07D333/40