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1.发明公开A PROCESS FOR THE PREPARATION OF OPTICALLY PURE R (-) SALBUTAMOL AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS 有权用于生产光学纯的R - （ - ） - 沙丁胺醇和其药学上可接受的盐
公开(公告)号：EP2099740A1
公开(公告)日：2009-09-16
申请号：EP06842766.5
申请日：2006-09-25
发明人： DESAI PARIMAL, Hansmukh , SALVI NARENDRA, Jagannath , PATRAVALE BHARATKUMAR, Surendra , SEETHARAMAN, Subramanian , PATIL DILIP, Jibhau , GHOGARE KHANDU, Shankar
IPC分类号： C07C213/10 , C07C215/60 , C07C217/70 , C07B57/00
CPC分类号： C07C213/10 , C07B57/00 , C07B2200/07 , C07C215/60 , C07C217/70 , C07C219/22
摘要： A process for the preparation of optically pure R (-) salbutamol of formula (6) and its pharmaceutically acceptable salts by using a (+) 4-nitro tartranilic acid as the resolving agent and a binary solvent system comprising alkyl acetate and C1 to C4 branched or normal chain alcohol for dissolution of the racemic mixture and resolving agent and purification of the 4-nitro tartranilic acid salt of R (-) salbutamol. 4-nitro tartranilic acid salt of R (-) salbutamol is converted into formic acid salt of R(-) 4-benzyl salbutamol followed by basification and debenzylation to form optically pure R(-) salbutamol. Optically pure (R) -salbutamol is obtained in good yield and high purity. The optically pure R(-) salbutamol is optionally converted into pharmaceutically acceptable salts.
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2.发明授权A PROCESS FOR THE PREPARATION OF OPTICALLY PURE R (-) SALBUTAMOL AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS 有权用于生产光学纯的R - （ - ） - 沙丁胺醇和其药学上可接受的盐
公开(公告)号：EP2099740B1
公开(公告)日：2013-08-14
申请号：EP06842766.5
申请日：2006-09-25
发明人： DESAI PARIMAL, Hansmukh , SALVI NARENDRA, Jagannath , PATRAVALE BHARATKUMAR, Surendra , SEETHARAMAN, Subramanian , PATIL DILIP, Jibhau , GHOGARE KHANDU, Shankar
IPC分类号： C07C213/10 , C07C215/60 , C07C217/70 , C07B57/00
CPC分类号： C07C213/10 , C07B57/00 , C07B2200/07 , C07C215/60 , C07C217/70 , C07C219/22
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