公开(公告)号：EP4442680A1

公开(公告)日：2024-10-09

申请号：EP22900244.9

申请日：2022-11-09

申请人： Abbisko Therapeutics Co., Ltd.

发明人： DENG, Haibing ,  YANG, Fei ,  ZHU, Wei ,  LIU, Xiaofeng ,  LIU, Jian ,  LI, Mingfeng ,  LIU, Zhaomin ,  YING, Haiyan ,  YU, Hongping ,  CHEN, Zhui ,  XU, Yaochang

IPC分类号： C07D237/32 ,  C07D401/14 ,  C07D401/04 ,  C07D471/14 ,  C07D471/04 ,  C07D487/04 ,  C07D498/04 ,  A61K31/502 ,  A61K31/517 ,  A61K31/519 ,  A61P35/00

CPC分类号： A61K31/502 ,  A61K31/517 ,  A61K31/519 ,  A61P35/00 ,  C07D237/32 ,  C07D401/04 ,  C07D401/14 ,  C07D471/04 ,  C07D471/14 ,  C07D487/04 ,  C07D498/04

摘要： A pyrazole derivative, and a preparation method therefor and a use thereof in medicine. In particular, the present invention relates to a PRMT5 inhibitor having a structure shown in formula (I), a preparation method therefor, a pharmaceutical composition containing same, a use thereof as a PRMT5 inhibitor, and a use thereof in treatment and/or prevention of a PRMT5-mediated disease.