公开(公告)号：EP2012824A2

公开(公告)日：2009-01-14

申请号：EP07755413.7

申请日：2007-04-10

申请人： Abbott Biotechnology Ltd.

发明人： WILLIAN, Mary, Kaye ,  OKUN, Martin, M. ,  HOFFMAN, Rebecca, S. ,  GU, Yihua ,  Camez, Anne ,  MELILLI Lisa E. ,  GORDON, Kenneth B.

IPC分类号： A61K39/395 ,  C07K16/18 ,  C07K16/24 ,  C07K16/00

CPC分类号： C07K16/241 ,  A61K2039/505 ,  A61K2039/545 ,  C07K2317/21 ,  C07K2317/565 ,  C07K2317/76

摘要： The invention provides methods, uses and compositions for the treatment of psoriasis. The invention describes methods and uses for treating psoriasis, wherein a TNFα inhibitor, such as a human TNFα antibody, or antigen-binding portion thereof, is used to treat psoriasis in a subject. Also described are methods for determining the efficacy of a TNFα inhibitor for treatment psoriasis in a subject.

公开(公告)号：EP2152318A2

公开(公告)日：2010-02-17

申请号：EP08768010.4

申请日：2008-05-30

申请人： Abbott Biotechnology Ltd.

发明人： OKUN, Martin, M. ,  MULANI, Parvez, M. ,  HOFFMAN, Rebecca, S. ,  CHAO, Jingdong ,  HARRIS, Thomas, C. ,  ASHRAF, Talat

IPC分类号： A61K49/00 ,  A61K39/395

CPC分类号： C07K16/241 ,  A61K2039/505

摘要： The invention provides methods, uses and compositions for the treatment of psoriasis or Crohn's disease. The invention describes methods and uses for treating psoriasis or Crohn's disease, wherein a TNFα inhibitor, such as a human TNFα antibody, or antigen-binding portion thereof, is used to treat psoriasis in a subject. The invention includes methods of improving patient reported outcomes using a human human TNFα antibody, or antigen-binding portion thereof, for the treatment of Crohn's or psoriasis. The invention also provides methods of improving fatigue or depression in patients having Crohns'.