公开(公告)号：EP1296954A1

公开(公告)日：2003-04-02

申请号：EP01954000.4

申请日：2001-07-02

申请人： Abbott GmbH & Co. KG

发明人： STEINER, Gerd ,  SCHELLHAAS, Kurt ,  SZABO, Laszlo ,  BEHL, Berthold ,  GARCIA-LADONA, Francisco, Javier ,  UNGER, Liliane

IPC分类号： C07D217/24 ,  A61K31/496 ,  A61P9/10 ,  C07D417/12 ,  C07D401/12 ,  C07D209/34 ,  C07D275/06 ,  C07D417/06 ,  C07D413/12 ,  A61K31/538 ,  A61K31/5415 ,  A61K31/553 ,  A61K31/554

CPC分类号： C07D275/06 ,  C07D209/34 ,  C07D217/24 ,  C07D401/12 ,  C07D413/12 ,  C07D417/06 ,  C07D417/12

摘要： Compounds of formula (I), wherein the ring with the increment (N-A) can be 5, 6 or 7-membered and can also contain an oxygen or sulfur atom or a C-C double bond, with the exception of the 1,4-benzoxazepine skeleton, A represents a carbonyl or sulfonyl group, Y is CH2, CH2-CH2, CH2-CH2-CH2 or CH2-CH, Z is a nitrogen atom, a carbon atom or CH and the bond between Y and Z can also be a double bond, n means the number 2, 3 or 4, R1 can be a hydrogen atom, halogen or a C¿1?-C4-alkyl, trifluoromethyl, hydroxy, C1-C4-alkoxy or amino group and R?2¿ represents a phenyl, pyridyl or pyrazinyl group which is optionally mono or di-substituted by C¿1?-C4-alkyl, trifluoromethyl, trifluoromethoxy, hydroxy, amino, monomethylamino, dimethylamino, cyano or nitro groups and which can be anellated with a benzole nucleus which can be mono or di-substituted by halogen atoms, C1-C4-alkyl, hydroxy, trifluoromethyl, C1-C4-alkoxy, amino, cyano or nitro groups and can optionally contain 1 nitrogen atom, or with a 5 or 6-membered ring which can contain 1 to 2 oxygen atoms; and physiologically compatible salts of these compounds show affinity for the 5-HT1A receptor and are suitable for treating cerebral ischaemia.