公开(公告)号：EP2299821A1

公开(公告)日：2011-03-30

申请号：EP09763424.0

申请日：2009-06-09

申请人： Abbott Laboratories

发明人： WISHART, Neil ,  ARGIRIADI, Maria, A. ,  CALDERWOOD, David, J. ,  ERICSSON, Anna, M. ,  FIAMENGO, Bryan, A. ,  FRANK, Kristine, E. ,  FRIEDMAN, Michael ,  GEORGE, Dawn, M. ,  GOEDKEN, Eric, R. ,  JOSEPHSOHN, Nathan, S. ,  LI, Biqin, C. ,  MORYTKO, Michael, J. ,  STEWART, Kent, D. ,  VOSS, Jeffrey, W. ,  WALLACE, Grier, A. ,  WANG, Lu ,  WOLLER, Kevin, R.

IPC分类号： A01N43/42

CPC分类号： C07D487/14 ,  C07D498/14 ,  C07D513/14

摘要： The invention provides a compound of Formula (I), pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variable are defined herein. The compounds of the invention are useful for treating immunological and oncological conditions.

公开(公告)号：EP1648905B1

公开(公告)日：2008-12-31

申请号：EP04779180.1

申请日：2004-07-26

申请人： ABBOTT LABORATORIES

发明人： BETSCHMANN, Patrick ,  BURCHAT, Andrew, F. ,  CALDERWOOD, David, J. ,  CURTIN, Michael, L. ,  DAVIDSEN, Steven, K. ,  DAVIS, Heather, M. ,  FREY, Robin, R. ,  HEYMAN, Howard, R. ,  HIRST, Gavin, C. ,  HRNCIAR, Peter ,  MICHAELIDES, Michael, R. ,  MUCKEY, Melanie, A. ,  RAFFERTY, Paul ,  WADA, Carol, K.

IPC分类号： C07D495/04 ,  C07D491/04 ,  C07D498/04 ,  A61K31/4355 ,  A61K31/4365 ,  A61P35/00

CPC分类号： C07D491/04 ,  C07D495/04

摘要： Compounds having the formula: (I), are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.

公开(公告)号：EP1928237A2

公开(公告)日：2008-06-11

申请号：EP06824879.8

申请日：2006-09-01

申请人： ABBOTT LABORATORIES

发明人： BRIENLINGER, Eric, C. ,  CALDERWOOD, David, J. ,  FRANK, Kristine, E. ,  BETSCHMANN, Patrick ,  HIRST, Gavin, C. ,  MORYTKO, Michael, J. ,  DIXON, Richard, W.

IPC分类号： A01N43/50

CPC分类号： C07D487/04

摘要： The present invention is directed to novel imidazopyrazine and imidazopyrimidine compounds of formula (I), wherein the variables are as defined herein. The compounds of formula (I) are useful as kinase inhibitors and as such would be useful in treating certain conditions and diseases, especially inflammatory conditions and diseases and proliferative disorders and conditions, for example, cancers.

公开(公告)号：EP2506716A1

公开(公告)日：2012-10-10

申请号：EP10835061.2

申请日：2010-12-01

申请人： Abbott Laboratories

发明人： WISHART, Neil ,  ARGIRIADI, Maria, A. ,  CALDERWOOD, David, J. ,  ERICSSON, Anna, M. ,  FIAMENGO, Bryan, A. ,  FRANK, Kristine, E. ,  FRIEDMAN, Michael ,  GEORGE, Dawn, M. ,  GOEDKEN, Eric, R. ,  JOSEPHSOHN, Nathan, S. ,  LI, Biqin, C. ,  MORYTKO, Michael, J. ,  STEWART, Kent, D. ,  VOSS, Jeffrey, W. ,  WALLACE, Grier, A. ,  WANG, Lu ,  WOLLER, Kevin, R.

IPC分类号： A01N43/58

CPC分类号： C07D487/14 ,  A61K31/437 ,  A61K31/4985 ,  A61K45/06 ,  C07D471/14 ,  C07D498/14 ,  C07D513/14

摘要： The invention provides compounds of Formula (I) and Formula (II), pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variable are defined herein. The compounds of the invention are useful for treating immunological and oncological conditions.

公开(公告)号：EP2506713A1

公开(公告)日：2012-10-10

申请号：EP10835075.2

申请日：2010-12-01

申请人： Abbott Laboratories

发明人： WISHART, Neil ,  ARGIRIADI, Maria, A. ,  BREINLINGER, Eric, C. ,  CALDERWOOD, David, J. ,  ERICSSON, Anna, M. ,  FIAMENGO, Bryan, A. ,  FRANK, Kristine, E. ,  FRIEDMAN, Michael ,  GEORGE, Dawn, M. ,  GOEDKEN, Eric, R. ,  JOSEPHSOHN, Nathan, S. ,  LI, Biqin, C. ,  MORYTKO, Michael, J. ,  MULLEN, Kelly, D. ,  SOMAL, Gagandeep ,  STEWART, Kent, D. ,  VOSS, Jeffrey, W. ,  WALLACE, Grier, A. ,  WANG, Lu ,  WOLLER, Kevin, R. ,  HOEMANN, Michael, Z.

IPC分类号： A01N43/42 ,  A61K31/44

CPC分类号： C07F9/06 ,  C07D471/14 ,  C07D487/14 ,  C07D498/14 ,  C07D513/14

摘要： The invention provides a compound of Formula (Ia), (Ib), (Ic), (Id), (Ie), (If), (Ig), (Ih), (Ii), (Ij), (Ik), or (Il) as defined herein, pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variable are defined herein. The compounds of the invention are useful for treating immunological and oncological conditions.

摘要翻译： 本发明提供了式（Ia），（Ib），（Ic），（Id），（Ie），（If），（Ig），（Ih），（Ii）， 或（II）化合物，其药学上可接受的盐，前药，生物活性代谢物，立体异构体和异构体，其中变量如本文所定义。 本发明的化合物可用于治疗免疫学和肿瘤学病症。

公开(公告)号：EP1648905A1

公开(公告)日：2006-04-26

申请号：EP04779180.1

申请日：2004-07-26

申请人： ABBOTT LABORATORIES

发明人： BETSCHMANN, Patrick ,  BURCHAT, Andrew, F. ,  CALDERWOOD, David, J. ,  CURTIN, Michael, L. ,  DAVIDSEN, Steven, K. ,  DAVIS, Heather, M. ,  FREY, Robin, R. ,  HEYMAN, Howard, R. ,  HIRST, Gavin, C. ,  HRNCIAR, Peter ,  MICHAELIDES, Michael, R. ,  MUCKEY, Melanie, A. ,  RAFFERTY, Paul ,  WADA, Carol, K.

IPC分类号： C07D495/04 ,  C07D491/04 ,  C07D498/04 ,  A61K31/4355 ,  A61K31/4365 ,  A61P35/00

CPC分类号： C07D491/04 ,  C07D495/04

摘要： Compounds having the formula: (I), are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.

摘要翻译： 具有式（I）的化合物可用于抑制蛋白酪氨酸激酶。 本发明还公开了制备所述化合物的方法，含有所述化合物的组合物以及使用所述化合物的治疗方法。