公开(公告)号：EP0821665A1

公开(公告)日：1998-02-04

申请号：EP96912978.0

申请日：1996-04-18

申请人： Abbott Laboratories

发明人： ARENDSEN, David, L. ,  BAKER, William, R. ,  FAKHOURY, Stephen, A. ,  FUNG, K., L., Anthony ,  GARVEY, David, S. ,  MCCLELLAN, William, J. ,  O'CONNOR, Stephen, J. ,  PRASAD, Rajnandan, N. ,  ROCKWAY, Todd, W. ,  ROSENBERG, Saul, H. ,  STEIN, Herman, H. ,  SHEN, Wang ,  STOUT, David, M. ,  SULLIVAN, Gerard, M. ,  AUGERI, David, J.

IPC分类号： A61K31 ,  A61P3 ,  A61P9 ,  A61P31 ,  A61P35 ,  A61P43 ,  C07C233 ,  C07C235 ,  C07D271 ,  C07D285 ,  C07D333

CPC分类号： C07C235/82 ,  C07C233/58 ,  C07C233/59 ,  C07C233/60 ,  C07C235/40 ,  C07C2601/04 ,  C07D333/20

摘要： The present invention provides a compound of formula (I) or (II) or a pharmaceutically acceptable salt thereof, which is useful for inhibiting protein farnesyltransferase and the farnesylation of the oncogene protein Ras or inhibiting de novo squalene production resulting in the inhibition of cholesterol biosynthesis, processes for the preparation of the compounds of the invention in addition to intermediates useful in these processes, a pharmaceutical composition, and to methods of using such compounds.

公开(公告)号：EP0821665B1

公开(公告)日：2001-10-04

申请号：EP96912978.2

申请日：1996-04-18

申请人： Abbott Laboratories

发明人： ARENDSEN, David, L. ,  BAKER, William, R. ,  FAKHOURY, Stephen, A. ,  FUNG, K., L., Anthony ,  GARVEY, David, S. ,  MCCLELLAN, William, J. ,  O'CONNOR, Stephen, J. ,  PRASAD, Rajnandan, N. ,  ROCKWAY, Todd, W. ,  ROSENBERG, Saul, H. ,  STEIN, Herman, H. ,  SHEN, Wang ,  STOUT, David, M. ,  SULLIVAN, Gerard, M. ,  AUGERI, David, J.

IPC分类号： C07C233/60 ,  C07D333/20 ,  C07C233/58 ,  C07C233/59 ,  C07C235/40 ,  A61K31/19 ,  A61K31/215 ,  A61K31/38 ,  A61K31/16

CPC分类号： C07C235/82 ,  C07C233/58 ,  C07C233/59 ,  C07C233/60 ,  C07C235/40 ,  C07C2601/04 ,  C07D333/20

摘要： The present invention provides a compound of formula (I) or (II) or a pharmaceutically acceptable salt thereof, which is useful for inhibiting protein farnesyltransferase and the farnesylation of the oncogene protein Ras or inhibiting de novo squalene production resulting in the inhibition of cholesterol biosynthesis, processes for the preparation of the compounds of the invention in addition to intermediates useful in these processes, a pharmaceutical composition, and to methods of using such compounds.

摘要翻译： 本发明提供式（II）化合物或其药学上可接受的盐，其可用于抑制蛋白质法呢基转移酶和癌基因蛋白Ras的法呢基化，制备本发明化合物的方法除了可用于 这些方法，药物组合物，以及使用这些化合物的方法。