专利检索 ap:("Abbott Laboratories" OR "Abbott GmbH & Co. KG") AND inv:"ST. JOHN MOORE, Nigel" 第 1 页

1.

发明公开
5-HETEROARYL SUBSTITUTED INDAZOLES AS KINASE INHIBITORS 审中-公开
标题翻译： 5-杂芳基取代的吲唑作为激酶抑制剂的

公开(公告)号：EP2167491A1

公开(公告)日：2010-03-31

申请号：EP08770094.4

申请日：2008-06-04

申请人： Abbott Laboratories , Abbott GmbH & Co. KG

发明人： AKRITOPOULOU-ZANZE, Irini , WAKEFIELD, Brian D , MACK, Helmut , TURNER, Sean C , GASIECKI, Alan F , GRACIAS, Vijaya J , SARRIS, Kathy , KALVIN, Douglas M , MICHMERHUIZEN, Melissa J , SHUAI, Qi , PATEL, Jyoti R , BAKKER, Margaretha , TEUSCH, Nicole , JOHNSON, Eric F. , KOVAR, Peter J , DJURIC, Stevan W , LONG, Andrew J , VASUDEVAN, Anil , HOBSON, Adrian , ST. JOHN MOORE, Nigel , WANG, Lu , GEORGE, Dawn , LI, Biqin , FRANK, Kristine

IPC分类号： C07D403/04 , C07D413/04 , C07D417/04

CPC分类号： C07D403/04 , C07D413/04 , C07D417/04

摘要： The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, wherein A, R1, R2, R3 and m, are defined in the description. The present invention relates also to methods of making said compounds, and compositions containing said compounds which are useful for inhibiting kinases such as Glycogen Synthase kinase 3 (GSK-3), Rho kinase (ROCK), Janus Kinases (JAK), AKT, PAK4, PLK, CK2, KDR, MK2, JNK1, aurora, pim 1 and nek 2.