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公开(公告)号：EP3072904A1
公开(公告)日：2016-09-28
申请号：EP16167670.5
申请日：2011-02-28
申请人： Abbvie Inc.
IPC分类号： C07K16/18 , C12N15/13 , A61K39/395
CPC分类号： C07K16/28 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K2317/24 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： DLL4 binding proteins are described herein, including antibodies, CDR-grafted antibodies, humanized antibodies, and DLL4 binding fragments thereof, proteins that bind DLL4 with high affinity, and DLL4 binding proteins that neutralize DLL4 and/or VEGF activity. The DLL4 binding proteins are useful for treating or preventing cancers and tumors and especially for treating or preventing tumor angiogenesis.
摘要翻译： 本文描述了DLL4结合蛋白，包括抗体，CDR-移植抗体，人源化抗体和其DLL4结合片段，以高亲和力结合DLL4的蛋白质，以及中和DLL4和/或VEGF活性的DLL4结合蛋白。 DLL4结合蛋白可用于治疗或预防癌症和肿瘤，特别是用于治疗或预防肿瘤血管生成。
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公开(公告)号：EP3680253A2
公开(公告)日：2020-07-15
申请号：EP20150745.6
申请日：2011-02-28
申请人： AbbVie Inc.
IPC分类号： C07K16/18
摘要： DLL4 binding proteins are described herein, including antibodies, CDR-grafted antibodies, humanized antibodies, and DLL4 binding fragments thereof, proteins that bind DLL4 with high affinity, and DLL4 binding proteins that neutralize DLL4 and/or VEGF activity. The DLL4 binding proteins are useful for treating or preventing cancers and tumors and especially for treating or preventing tumor angiogenesis.
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公开(公告)号：EP2542582A2
公开(公告)日：2013-01-09
申请号：EP11751147.7
申请日：2011-02-28
申请人： Abbvie Inc.
IPC分类号： C07K16/18
CPC分类号： C07K16/28 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K2317/24 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： DLL4 binding proteins are described herein, including antibodies, CDR-grafted antibodies, humanized antibodies, and DLL4 binding fragments thereof, proteins that bind DLL4 with high affinity, and DLL4 binding proteins that neutralize DLL4 and/or VEGF activity. The DLL4 binding proteins are useful for treating or preventing cancers and tumors and especially for treating or preventing tumor angiogenesis.
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公开(公告)号：EP3680253A3
公开(公告)日：2020-09-30
申请号：EP20150745.6
申请日：2011-02-28
申请人： AbbVie Inc.
IPC分类号： C07K16/18
摘要： DLL4 binding proteins are described herein, including antibodies, CDR-grafted antibodies, humanized antibodies, and DLL4 binding fragments thereof, proteins that bind DLL4 with high affinity, and DLL4 binding proteins that neutralize DLL4 and/or VEGF activity. The DLL4 binding proteins are useful for treating or preventing cancers and tumors and especially for treating or preventing tumor angiogenesis.
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公开(公告)号：EP3468599A2
公开(公告)日：2019-04-17
申请号：EP17739394.9
申请日：2017-06-08
申请人： AbbVie Inc.
发明人： BENATUIL, Lorenzo , BRUNCKO, Milan , JUDD, Andrew, S. , LI, Yingchun , MCCLUSKEY, Andrew , PHILLIPS, Andrew, C. , PHILLIPS, Darren, C. , SEAGAL, Jane , SOUERS, Andrew, J.
IPC分类号： A61K39/395 , A61K31/337 , C07K16/28 , A61K47/68
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公开(公告)号：EP3468598A1
公开(公告)日：2019-04-17
申请号：EP17739393.1
申请日：2017-06-08
申请人： AbbVie Inc.
发明人： BENATUIL, Lorenzo , BRUNCKO, Milan , DOHERTY, George , FREY, Robin, R. , JUDD, Andrew, S. , LI, Yingchun , MCCLUSKEY, Andrew , PHILLIPS, Andrew, C. , PHILLIPS, Darren, C. , SONG, Xiaohong , SEAGAL, Jane , SOUERS, Andrew, J. , SULLIVAN, Gerard, M. , TAO, Zhi-fu
IPC分类号： A61K39/395 , A61K31/337 , C07K16/28 , A61K47/68
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公开(公告)号：EP3468596A2
公开(公告)日：2019-04-17
申请号：EP17733668.2
申请日：2017-06-08
申请人： AbbVie Inc.
发明人： BENATUIL, Lorenzo , BRUNCKO, Milan , JUDD, Andrew, S. , LI, Yingchun , MCCLUSKEY, Andrew , PHILLIPS, Andrew, C. , PHILLIPS, Darren, C. , SEAGAL, Jane , SOUERS, Andrew, J.
IPC分类号： A61K39/395 , A61K31/337 , C07K16/28 , A61K47/68
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公开(公告)号：EP3029070A1
公开(公告)日：2016-06-08
申请号：EP15203274.4
申请日：2010-08-27
申请人： AbbVie Inc.
发明人： BENATUIL, Lorenzo , BOGHAERT, Erwin, R. , GU, Jijie , HARRIS, Maria , HICKSON, Jonathan, A. , HSIEH, Chung-Ming , KUTSKOVA, Yuliya , LI, Yingchun , LIU, Zhihong , MORGAN-LAPPE, Susan
IPC分类号： C07K16/28 , C07K16/18 , A61K39/395 , A61K45/06 , C07K16/22 , C07K7/06 , C07K7/08 , C07K14/47
CPC分类号： C07K16/22 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K7/06 , C07K7/08 , C07K14/47 , C07K16/18 , C07K2317/21 , C07K2317/33 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： Improved DLL4 binding proteins are described, including antibodies, CDR-grafted antibodies, human antibodies, and DLL4 binding fragments thereof, proteins that bind DLL4 with high affinity, and DLL4 binding proteins that neutralize DLL4 activity. The DLL4 binding proteins are useful for treating or preventing cancers and tumors and especially for treating or preventing tumor angiogenesis, and/or other angiogenesis-dependent diseases such as ocular neovascularization, or angiogenesis-independent diseases characterized by aberrant DLL4 expression or activity such as autoimmune disorders including multiple sclerosis.
摘要翻译： 描述了改进的DLL4结合蛋白，包括抗体，CDR-移植抗体，人抗体和DLL4结合片段，以高亲和力结合DLL4的蛋白质，以及中和DLL4活性的DLL4结合蛋白。 DLL4结合蛋白可用于治疗或预防癌症和肿瘤，特别是用于治疗或预防肿瘤血管生成和/或其它血管生成依赖性疾病如眼新生血管形成或以异常DLL4表达或活性为特征的血管生成非依赖性疾病，例如自身免疫 包括多发性硬化的疾病。
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9.发明公开ANTI-VEGF/DLL4 DUAL VARIABLE DOMAIN IMMUNOGLOBULINS AND USES THEREOF 审中-公开IMMUNGLOBULINE MIT ZWEIFACHER VARIABLER ANTI-VEGF / DLL4-DOMÄNEUND VERWENDUNGEN DAVON
公开(公告)号：EP2914625A2
公开(公告)日：2015-09-09
申请号：EP13789683.3
申请日：2013-10-31
申请人： AbbVie Inc.
发明人： HICKSON, Jonathan, A. , HAASCH, Deanna, L. , GUPTA, Supriya , CHARI, Ravi , ZAMIRI, Camellia , GU, Jijie , AMBROSI, Dominic, J. , LAPPE, Susan, E. , LI, Yingchun , NAUMOVSKI, Louie , CAO, Xianhua
CPC分类号： C07K16/468 , A61K31/337 , A61K31/4745 , A61K31/495 , A61K31/513 , A61K31/525 , A61K31/7068 , A61K39/395 , A61K39/3955 , A61K39/39591 , A61K45/06 , A61K2039/505 , C07K16/22 , C07K16/28 , C07K2317/24 , C07K2317/31 , C07K2317/35 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/64 , C07K2317/76 , C07K2317/92 , C07K2317/94 , A61K2300/00
摘要： Disclosed herein are multivalent and multispecific binding proteins, methods of making the binding proteins, and their uses in the diagnosis, monitoring, inhibition, prevention and/or treatment of cancers, tumors, and/or other angiogenesis-dependent diseases characterized by aberrant DLL4 and/or VEGF expression or activity.
摘要翻译： 本文公开了多价和多特异性结合蛋白，制备结合蛋白的方法及其在诊断，监测，抑制，预防和/或治疗癌症，肿瘤和/或其他血管发生依赖性疾病中的用途，其特征在于异常DLL4和 /或VEGF表达或活性。
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10.发明公开Dual Variable Domain Immunoglobulins and uses thereof 审中-公开Immunglobuline mit zweifacher variablerDomäneund Verwendungen davon
公开(公告)号：EP2899209A1
公开(公告)日：2015-07-29
申请号：EP15153941.8
申请日：2009-04-28
申请人： Abbvie Inc.
发明人： GHAYUR, Tariq , MORGAN-LAPPE, Susan, E. , REILLY, Edward, B. , KINGSBURY, Gillian, A. , PHILLIPS, Andrew , WANG, Jieyi , BELL, Randy, L. , NORVELL, Suzanne, M. , LI, Yingchun , LIU, Junjian , YING, Hua
CPC分类号： C07K16/468 , A61K39/39533 , A61K45/06 , A61K2039/505 , C07K16/22 , C07K16/28 , C07K16/2863 , C07K16/32 , C07K2317/31 , C07K2317/565 , C07K2317/64 , C07K2317/71 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/92 , C07K2319/00 , G01N33/6872 , G01N33/74 , G01N2333/515 , G01N2333/705 , Y02A50/386 , Y02A50/41 , Y02A50/412 , Y02A50/58 , Y10S435/81
摘要： The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.
摘要翻译： 本发明涉及工程化的多价和多特异性结合蛋白，制备方法，具体涉及用于预防，诊断和/或治疗疾病的用途。
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