专利检索 ap:("Abgenix, Inc.") AND inv:"BHAKTA, Sunil" 第 1 页

1.

发明公开
ANTIBODIES DIRECTED TO MONOCYTE CHEMO-ATTRACTANT PROTEIN-1 (MCP-1) AND USES THEREOF 审中-公开
标题翻译：抗体的吸引力单核细胞化疗蛋白-1（MCP-1）及其用途

公开(公告)号：EP1542724A2

公开(公告)日：2005-06-22

申请号：EP03788686.8

申请日：2003-08-19

申请人： Abgenix, Inc.

发明人： GUDAS, Jean, M. , HAAK-FRENDSCHO, Mary , FOORD, Orit , LIANG, Meina, L. , AHLUWALIA, Kiran , BHAKTA, Sunil

IPC分类号： A61K39/395 , C07K16/00 , G01N33/53

CPC分类号： C07K16/24 , A61K2039/505 , C07K2317/21 , C07K2317/34 , C07K2317/56 , C07K2317/565

摘要： Embodiments of the invention described herein relate to antibodies directed to the antigen monocyte chemo-attractant protein-1 (MCP-1) and uses of such antibodies. In particular, in accordance with some embodiments, there are provided fully human monoclonal antibodies directed to the antigen MCP-1. Nucelotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDRs), specifically from FR1 through FR4 or CDR1 through CDR3, are provided. Hybridomas or other cell lines expressing such immunoglobulin molecules and monoclonal antibodies are also provided.