公开(公告)号：EP1105427A2

公开(公告)日：2001-06-13

申请号：EP99943743.7

申请日：1999-08-17

申请人： Abgenix, Inc.

发明人： GALLO, Michael ,  JUNGHANS, Richard ,  FOORD, Orit

IPC分类号： C07K16/42 ,  C07K16/24 ,  C12N15/19 ,  C12N15/66

CPC分类号： C07K16/244 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/52 ,  C07K2317/55 ,  C07K2319/00

摘要： In accordance with the present invention, there are provided methods for the extension of serum half-lives of proteinaceous molecules, particularly antibody molecules, and compositions of molecules modified in accordance with the methods of the invention. In accordance with a first aspect of the present invention, there is provided a method of modifying the half-life of an antibody through providing an antibody containing an FcRn binding domain or the genes encoding such antibody and physically linking the antibody or the antibody as encoded to a second FcRn binding domain. In accordance with a second aspect of the present invention, there is provided a molecule that contains at least two distinct FcRn binding moieties.