专利检索 ap:("Academisch Ziekenhuis Leiden (also acting under the name of Leiden University Medical)") AND inv:"ZALDUMBIDE, Arnaud" 第 1 页

1.

发明公开
INSULIN GENE-DERIVED PROTEINS AND PEPTIDES FOR USE IN THE DIAGNOSIS AND TREATMENT OF TYPE 1 DIABETES 审中-公开

公开(公告)号：EP3405483A2

公开(公告)日：2018-11-28

申请号：EP17701674.8

申请日：2017-01-20

申请人： Academisch Ziekenhuis Leiden (also acting under the name of Leiden University Medical)

发明人： ROEP, Bart Otto , VAN LUMMEL, Menno , VAN VEELEN, Peter Antonis , ZALDUMBIDE, Arnaud

IPC分类号： C07K14/62 , A61K38/08 , A61K38/10 , A61K38/28 , C07K7/06 , C07K7/08

CPC分类号： C07K14/62 , A61K35/15 , A61K38/00 , C07K7/06 , C07K7/08 , C12N2510/00 , G01N33/50

摘要： The present invention relates to the identification of novel peptides derived from aberrant proteins involved in Type 1 Diabetes mellitus (T1D), also known as defective ribosomal products (DRiPs). In particular the invention relates to epitopes present in DRiPs of the human preproinsulin (PPI) mRNA, its representative peptides and the use thereof in diagnosis, prevention and/or treatment of T1D. Moreover, the inventions relate to antibodies and antisera against the identified epitopes and the use thereof in the diagnosis of T1D.