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公开(公告)号：EP4186915A1
公开(公告)日：2023-05-31
申请号：EP21841411.8
申请日：2021-07-15
申请人： Sichuan University , Academy of Military Medical Sciences , Chengdu Aupone Pharmaceutical Co., Ltd.
发明人： QIN, Yong , ZHONG, Wu , XUE, Fei , LIU, Xiaoyu , WANG, Yu , ZHOU, Xiaohan , LIU, Bo , WANG, Ke , YANG, Likai , ZHOU, Ruijie , XIAO, Yaxin , XUE, Fanglin , ZHANG, Minjie , SONG, Hao , ZHENG, Zhibing , LI, Song
摘要： Disclosed is a method for preparing a C-nucleoside compound represented by Formula (III) or salt thereof. The present method has a high reaction yield, is simple to operate, uses a single metal reagent, has stable reaction temperature conditions, does not require frequent changes to the reaction system during the operation process, is suitable for scale-up synthesis, is suitable for large-scale production of Remdesivir, and has low costs.
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2.发明公开
公开(公告)号：EP4183792A1
公开(公告)日：2023-05-24
申请号：EP20944871.1
申请日：2020-07-14
发明人： LIU, Xiaoyu , QIN, Yong , ZHONG, Wu , CAO, Ruiyuan , HE, Huan , ZHENG, Zhibing , LI, Song
摘要： The invention relates to a compound represented by general Formula I, a stereoisomer thereof, a pharmaceutically acceptable salt thereof, a pharmaceutically acceptable ester thereof, a pharmaceutically acceptable hydrate thereof or pharmaceutically acceptable solvate thereof, and the invention also relates to a pharmaceutical composition comprising the compound, and a preparation method for the compound and a use of the compound.
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公开(公告)号：EP4190785A1
公开(公告)日：2023-06-07
申请号：EP21850321.7
申请日：2021-07-22
发明人： QIN, Yong , ZHONG, Wu , XUE, Fei , ZHANG, Minjie , FAN, Shiyong , ZHENG, Zhibing , LI, Song
IPC分类号： C07D487/04
摘要： The present invention relates to the technical field of chemical drug synthesis, and specifically relates to a method for preparing a compound as shown in formula I, comprising: treating the compound as shown in formula VII with an acid to generate the compound as shown in formula I. The method has few synthetic process steps, raw materials which is stable and is easy to prepare, a reaction process which is easy to control, and a high overall yield and purity, and is suitable for industrial preparation.
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公开(公告)号：EP4186496A1
公开(公告)日：2023-05-31
申请号：EP21847141.5
申请日：2021-07-19
发明人： ZHONG, Wu , QIN, Yong , WANG, Manli , CAO, Ruiyuan , FAN, Shiyong , HU, Zhihong , LI, Song
摘要： The present application relates to use of cannabidiol in the preparation of a drug for treating coronavirus infections. The present invention specifically relates to cannabidiol, or a geometric isomer, pharmaceutically acceptable salt, solvate or hydrate thereof, or use of a pharmaceutical composition comprising any one or more of the above components in the preparation of a drug for preventing and/or treating diseases or infections caused by a coronavirus.
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