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公开(公告)号：EP1461318B9
公开(公告)日：2005-12-28
申请号：EP02794441.2
申请日：2002-12-23
IPC分类号： C07D215/00
CPC分类号： C07D451/02 , C07D401/04 , C07D413/06 , C07D417/06 , C07D513/04
摘要： The present invention relates to tetrahydroquinoline compounds as formulas I, as well as salts and isomers thereof wherein m is 0, 1 or 2; C3-C4 is CH2-CH or CH=Cor C4 is CH and C3 is absent; L1 and L2 are biradicals independently selected from the group consisting of -C(R6)=C(R7), -C(R6)=N, -N=C(R6)-, -S-, -NH- and -O-; wherein only one of L1 and L2 may be selected from the group consisting of -S-, NH - and O; Y is selected from the group consisting of O, S, and H2; X is a biradical as muscarinic receptor agonists; compositions comprising the same; methods of inhibiting an activity of a muscarinic receptor with said compounds; methods of treating a disease condition associated with a muscarinic receptor using said compounds; and methods for identifying a subject suitable for treatment using said compounds.
摘要翻译： 本发明涉及式I的四氢喹啉化合物及其盐和异构体，其中m为0,1或2; C 3 -C 4是CH 2 -CH或CH = C 1 -C 4是CH且C 3不存在; L1和L2是独立地选自-C（R6）= C（R7），-C（R6）= N，-N = C（R6） - ， - S - ， - NH-和-O- - ; 其中L1和L2中只有一个可以选自-S-，NH-和O; Y选自O，S和H 2; X是一种双基作为毒蕈碱受体激动剂; 包含其的组合物; 用所述化合物抑制毒蕈碱受体活性的方法; 使用所述化合物治疗与毒蕈碱受体相关的疾病状况的方法; 以及使用所述化合物鉴定适于治疗的受试者的方法。
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公开(公告)号：EP1461318B1
公开(公告)日：2005-09-14
申请号：EP02794441.2
申请日：2002-12-23
IPC分类号： C07D215/00
CPC分类号： C07D451/02 , C07D401/04 , C07D413/06 , C07D417/06 , C07D513/04
摘要： The present invention relates to tetrahydroquinoline compounds as formulas I, as well as salts and isomers thereof wherein m is 0, 1 or 2; C3-C4 is CH2-CH or CH=Cor C4 is CH and C3 is absent; L1 and L2 are biradicals independently selected from the group consisting of -C(R6)=C(R7), -C(R6)=N, -N=C(R6)-, -S-, -NH- and -O-; wherein only one of L1 and L2 may be selected from the group consisting of -S-, NH - and O; Y is selected from the group consisting of O, S, and H2; X is a biradical as muscarinic receptor agonists; compositions comprising the same; methods of inhibiting an activity of a muscarinic receptor with said compounds; methods of treating a disease condition associated with a muscarinic receptor using said compounds; and methods for identifying a subject suitable for treatment using said compounds.
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公开(公告)号：EP1461318A2
公开(公告)日：2004-09-29
申请号：EP02794441.2
申请日：2002-12-23
IPC分类号： C07D215/00
CPC分类号： C07D451/02 , C07D401/04 , C07D413/06 , C07D417/06 , C07D513/04
摘要： The present invention relates to tetrahydroquinoline compounds as formulas I, as well as salts and isomers thereof wherein m is 0, 1 or 2; C3-C4 is CH2-CH or CH=Cor C4 is CH and C3 is absent; L1 and L2 are biradicals independently selected from the group consisting of -C(R6)=C(R7), -C(R6)=N, -N=C(R6)-, -S-, -NH- and -O-; wherein only one of L1 and L2 may be selected from the group consisting of -S-, NH - and O; Y is selected from the group consisting of O, S, and H2; X is a biradical as muscarinic receptor agonists; compositions comprising the same; methods of inhibiting an activity of a muscarinic receptor with said compounds; methods of treating a disease condition associated with a muscarinic receptor using said compounds; and methods for identifying a subject suitable for treatment using said compounds.
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公开(公告)号：EP1828176A1
公开(公告)日：2007-09-05
申请号：EP05854098.0
申请日：2005-12-15
IPC分类号： C07D413/06 , C07D401/06 , C07D451/02 , C07D451/06 , A61K31/4709 , A61K31/538 , A61P25/28 , A61P25/18
CPC分类号： C07D413/06 , C07D401/04 , C07D401/06 , C07D417/06 , C07D451/02 , C07D451/04 , C07D451/06
摘要： The present invention relates to tetrahydroquinoline compounds as muscarinic receptor agonists; compositions comprising the same; methods of inhibiting an activity of a muscarinic receptor with said compounds; methods of treating a disease condition associated with a muscarinic receptor using said compounds; and methods for identifying a subject suitable for treatment using said compounds.
摘要翻译： 本发明涉及作为毒蕈碱受体激动剂的四氢喹啉化合物; 包含其的组合物; 用所述化合物抑制毒蕈碱受体活性的方法; 使用所述化合物治疗与毒蕈碱受体相关的疾病状况的方法; 以及使用所述化合物鉴定适于治疗的受试者的方法。
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