公开(公告)号：EP3054954A1

公开(公告)日：2016-08-17

申请号：EP14853051.2

申请日：2014-10-07

申请人： Acetylon Pharmaceuticals, Inc. ,  Moffitt Cancer Center

发明人： QUAYLE, Steven Norman ,  JONES, Simon S. ,  SOTOMAYOR, Eduardo M. ,  PINILLA-IBARZ, Javier ,  SAHAKIAN, Eva

IPC分类号： A61K31/505 ,  A61K31/519 ,  A61P35/00

CPC分类号： C07D239/42 ,  A61K31/505 ,  A61K31/519 ,  A61K2300/00

摘要： The invention relates to HDAC inhibitors, or combinations comprising an HDAC inhibitor and a BTK inhibitor for the treatment of non-hodgkin's lymphoma in a subject in need thereof. Also provided herein are methods for treating non-hodgkin's lymphoma in a subject in need thereof comprising administering to the subject a therapeutically effective amount of an HDAC inhibitor, or a combination comprising an HDAC inhibitor and a BTK inhibitor.

摘要翻译： 本发明涉及HDAC抑制剂，或BTK抑制剂的HDAC抑制剂的组合，其包括与用于在需要其的受试者中治疗非霍奇金淋巴瘤的。 所以提供了用于在有此需要的受试者中治疗非霍奇金氏淋巴瘤，其包括施用给所述受试者治疗有效量的HDAC抑制剂，或包含HDAC抑制剂和BTK抑制剂的组合的方法。

公开(公告)号：EP3054953A1

公开(公告)日：2016-08-17

申请号：EP14852240.2

申请日：2014-10-08

申请人： Acetylon Pharmaceuticals, Inc.

发明人： QUAYLE, Steven Norman ,  JONES, Simon S.

IPC分类号： A61K31/505 ,  A61K31/519 ,  A61K31/52 ,  A61K47/00 ,  A61K35/00

CPC分类号： C07D239/42 ,  A61K31/505 ,  A61K31/519 ,  A61K31/52 ,  A61K31/5377 ,  A61K45/06 ,  A61K2300/00

摘要： The invention relates to HDAC inhibitors, or combinations comprising an HDAC inhibitor and a PI3K inhibitor for the treatment of non-hodgkin's lymphoma in a subject in need thereof. Also provided herein are methods for treating non-hodgkin's lymphoma in a subject in need thereof comprising administering to the subject a therapeutically effective amount of an HDAC inhibitor, or a combination comprising an HDAC inhibitor and a PI3K inhibitor.

公开(公告)号：EP3054939A1

公开(公告)日：2016-08-17

申请号：EP14851888.9

申请日：2014-10-07

申请人： Acetylon Pharmaceuticals, Inc.

发明人： QUAYLE, Steven Norman ,  JONES, Simon Stewart ,  ANDERSON, Kenneth C. ,  HIDESHIMA, Teru

IPC分类号： A61K31/16 ,  A61K31/505 ,  A61P35/00

CPC分类号： A61K31/505 ,  A61K31/454 ,  A61K31/573 ,  C07D239/42 ,  C07D401/04 ,  A61K2300/00

摘要： The invention relates to combinations comprising an HDAC inhibitor and an immunomodulatory drug for the treatment of multiple myeloma in a subject in need thereof. The combinations may, optionally, further comprise an anti-inflammatory agent, such as dexamethasone. Also provided herein are methods for treating multiple myeloma in a subject in need thereof comprising administering to the subject an effective amount of one of the above combinations.

摘要翻译： 本发明涉及包含HDAC抑制剂和用于在有需要的受试者中治疗多发性骨髓瘤的免疫调节药物的组合。 组合可以任选地进一步包含抗炎剂，例如地塞米松。 本文还提供了在有需要的受试者中治疗多发性骨髓瘤的方法，包括向受试者施用有效量的上述组合之一。