公开(公告)号：EP2847162A1

公开(公告)日：2015-03-18

申请号：EP13724478.6

申请日：2013-05-09

申请人： Achaogen, Inc.

发明人： PATTERSON, Brian, D. ,  LU, Qing ,  AGGEN, James, Bradley ,  DOZZO, Paola ,  KASAR, Ramesh, Annasaheb ,  LINSELL, Martin, Sheringham ,  KANE, Timothy, Robert ,  GLIEDT, Micah, James ,  HILDEBRANDT, Darin, James ,  MCENROE, Glenn, A. ,  COHEN, Frederick ,  MOSER, Heinz, E.

IPC分类号： C07C259/06 ,  C07D233/64 ,  C07D261/08 ,  A61K31/16

CPC分类号： C07C235/66 ,  C07C259/06 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2601/16 ,  C07D233/64 ,  C07D261/08

摘要： Antibacterial compounds of formula (I) are provided, as well as stereoisomers and pharmaceutically acceptable salts thereof; pharmaceutical compositions comprising such compounds; methods of treating bacterial infections by the administration of such compounds; and processes for the preparation of such compounds.

摘要翻译： 提供式（I）的抗菌化合物：及其立体异构体及其药学上可接受的盐; 包含这些化合物的药物组合物; 通过施用这些化合物治疗细菌感染的方法; 以及这些化合物的制备方法。

公开(公告)号：EP2250171A2

公开(公告)日：2010-11-17

申请号：EP09743117.5

申请日：2009-02-12

申请人： Achaogen, Inc.

发明人： WAGMAN, Allan, Scott ,  MOSER, Heinz, Ernst ,  MCENROE, Glenn, A. ,  AGGEN, James ,  LINSELL, Martin, S ,  GOLDBLUM, Adam, Aaron ,  GRIFFIN, John, H. ,  SIMONS, Lloyd, J. ,  BELLIOTTI, Thomas, R. ,  HARRIS, Christina, R. ,  POEL, Toni-Jo ,  MELNICK, Michael, J. ,  GASTON, Ricky, D.

IPC分类号： C07D471/14 ,  C07D498/14 ,  C07D513/14 ,  A61K31/554 ,  A61P31/04

CPC分类号： C07D471/14 ,  C07D498/14 ,  C07D513/14

摘要： Compounds having antibacterial activity are disclosed. The compunds have the following structure (I): including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein A, B, D, E, G, R
1 , R
2 , R
3 , R
4 , R
5 , R
6 and R
7 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.