公开(公告)号：EP3340982A1

公开(公告)日：2018-07-04

申请号：EP16840164.4

申请日：2016-08-25

申请人： Achillion Pharmaceuticals, Inc.

发明人： WILES, Jason, Allan ,  PHADKE, Avinash, S. ,  DESHPANDE, Milind ,  AGARWAL, Atul ,  CHEN, Dawei ,  GADHACHANDA, Venkat, Rao ,  HASHIMOTO, Akihiro ,  PAIS, Godwin ,  WANG, Qiuping ,  WANG, Xiangzhu ,  GREENLEE, William

IPC分类号： A61K31/40 ,  A61K31/167 ,  A61K31/395 ,  C07D401/14 ,  C07D403/14 ,  C07D471/04

CPC分类号： C07D209/12 ,  A61K45/06 ,  A61P1/16 ,  C07D207/16 ,  C07D231/56 ,  C07D401/06 ,  C07D401/12 ,  C07D403/06 ,  C07D403/14 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D495/04 ,  C07D513/04

摘要： Compounds, methods of use, and processes for making inhibitors of complement Factor D are provided comprising Formula I, I″ and I′″ or a pharmaceutically acceptable salt or composition thereof. The inhibitors described herein target Factor D and inhibit or regulate the complement cascade. The inhibitors of Factor D described herein reduces the excessive activation of complement.

公开(公告)号：EP3589628A1

公开(公告)日：2020-01-08

申请号：EP18761960.6

申请日：2018-03-01

申请人： Achillion Pharmaceuticals, Inc.

发明人： WILES, Jason, Allan ,  PHADKE, Avinash, S. ,  DESHPANDE, Milind ,  AGARWAL, Atul ,  CHEN, Dawei ,  GADHACHANDA, Venkat, Rao ,  HASHIMOTO, Akihiro ,  PAIS, Godwin ,  WANG, Qiuping ,  WANG, Xiangzhu ,  BARRISH, Joel, Charles ,  GREENLEE, William ,  EASTMAN, Kyle, J.

IPC分类号： C07D403/08 ,  C07F9/572

公开(公告)号：EP3340983A1

公开(公告)日：2018-07-04

申请号：EP16840165.1

申请日：2016-08-25

申请人： Achillion Pharmaceuticals, Inc.

发明人： WILES, Jason, Allan ,  PHADKE, Avinash, S. ,  DESHPANDE, Milind ,  AGARWAL, Atul ,  CHEN, Dawei ,  GADHACHANDA, Venkat, Rao ,  HASHIMOTO, Akihiro ,  PAIS, Godwin ,  WANG, Qiuping ,  WANG, Xiangzhu ,  GREENLEE, William

IPC分类号： A61K31/40 ,  A61K31/167 ,  A61K31/395 ,  C07D401/14 ,  C07D403/14 ,  C07D471/04

CPC分类号： C07D403/04 ,  A61P1/16 ,  A61P29/00 ,  A61P37/00 ,  C07D401/14 ,  C07D403/10 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D407/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D487/22 ,  C07D493/04 ,  C07D513/04 ,  C07D519/00 ,  C07F9/65583

摘要： Compounds, methods of use, and processes for making inhibitors of complement Factor D are provided comprising Formula I, I″ and I′″ or a pharmaceutically acceptable salt or composition thereof. The inhibitors described herein target Factor D and inhibit or regulate the complement cascade. The inhibitors of Factor D described herein reduces the excessive activation of complement.