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1.发明公开2-PHENOXY- AND 2-PHENYLSULFOMAMIDE DERIVATIVES WITH CCR3 ANTAGONISTIC ACTIVITY FOR THE TREATMENT OF ASTHMA AND OTHER INFLAMMATORY OR IMMUNOLOGICAL DISORDERS 有权2-苯氧基和2 - 苯 - BENZENESULFONAMID与CCR3拮抗活性衍生物治疗哮喘和其它炎症或免疫性疾病
公开(公告)号：EP1608374A1
公开(公告)日：2005-12-28
申请号：EP04719389.1
申请日：2004-03-11
发明人： LI, Yingfu , BACON, Kevin , SUGIMOTO, Hiromi , FUKUSHIMA, Keiko , HASHIMOTO, Kentaro , MARUMO, Makiko , MORIWAKI, Toshiya , NUNAMI, Noriko , TSUNO, Naoki , URBAHNS, Klaus , YOSHIDA, Nagahiro
IPC分类号： A61K31/4965 , A61K31/439 , A61K31/4015 , A61K31/405 , A61K31/497 , C07C311/37 , C07D241/04 , C07D453/02 , C07D207/40 , C07D403/06 , C07D487/04 , C07D401/04 , C07D243/08 , C07D403/04 , C07D207/34
CPC分类号： C07D487/04 , A61K31/439 , C07C311/29 , C07D207/12 , C07D207/14 , C07D207/16 , C07D207/40 , C07D207/404 , C07D207/48 , C07D211/54 , C07D223/12 , C07D241/04 , C07D243/08 , C07D257/04 , C07D295/13 , C07D295/22 , C07D295/26 , C07D303/06 , C07D303/36 , C07D401/04 , C07D401/06 , C07D401/14 , C07D403/06 , C07D403/12 , C07D453/02 , C07D487/02 , C07D487/08
摘要： The present invention relates to a benzenesulfonamide derivative of formula (I), which is useful as an active ingredient of pharmaceutical preparations. The benzenesulfonamide derivatives of the present invention have CCR3 (CC type chemokine receptor) antagonistic activity, and can be used for the prophylaxis and treatment of diseases associated with CCR3 activity, in particular for the treatment of asthma, atopic dermatitis, allergic rhinitis and other inflammatory/immunological disorders. In said formula, X represents O or S; R4 represents formulae (a), (b), (c), (d), (e), (f), (g), (h), (i) or (j), the other substituents are as defined in claim 1.
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2.发明授权2-PHENOXY- AND 2-PHENYLSULFOMAMIDE DERIVATIVES WITH CCR3 ANTAGONISTIC ACTIVITY FOR THE TREATMENT OF ASTHMA AND OTHER INFLAMMATORY OR IMMUNOLOGICAL DISORDERS 有权2-苯氧基和2 - 苯 - BENZENESULFONAMID与CCR3拮抗活性衍生物治疗哮喘和其它炎症或免疫性疾病
公开(公告)号：EP1608374B1
公开(公告)日：2008-11-05
申请号：EP04719389.1
申请日：2004-03-11
发明人： LI, Yingfu , BACON, Kevin , SUGIMOTO, Hiromi , FUKUSHIMA, Keiko , HASHIMOTO, Kentaro , MARUMO, Makiko , MORIWAKI, Toshiya , NUNAMI, Noriko, 56 Sumitomo-Seiyaku , TSUNO, Naoki , URBAHNS, Klaus , YOSHIDA, Nagahiro
IPC分类号： A61K31/4965 , A61K31/439 , A61K31/4015 , A61K31/405 , A61K31/497 , C07C311/37 , C07D241/04 , C07D453/02 , C07D207/40 , C07D403/06 , C07D487/04 , C07D401/04 , C07D243/08 , C07D403/04 , C07D207/34
CPC分类号： C07D487/04 , A61K31/439 , C07C311/29 , C07D207/12 , C07D207/14 , C07D207/16 , C07D207/40 , C07D207/404 , C07D207/48 , C07D211/54 , C07D223/12 , C07D241/04 , C07D243/08 , C07D257/04 , C07D295/13 , C07D295/22 , C07D295/26 , C07D303/06 , C07D303/36 , C07D401/04 , C07D401/06 , C07D401/14 , C07D403/06 , C07D403/12 , C07D453/02 , C07D487/02 , C07D487/08
摘要： The present invention relates to a benzenesulfonamide derivative of formula (I), which is useful as an active ingredient of pharmaceutical preparations. The benzenesulfonamide derivatives of the present invention have CCR3 (CC type chemokine receptor) antagonistic activity, and can be used for the prophylaxis and treatment of diseases associated with CCR3 activity, in particular for the treatment of asthma, atopic dermatitis, allergic rhinitis and other inflammatory/immunological disorders. In said formula, X represents O or S; R4 represents formulae (a), (b), (c), (d), (e), (f), (g), (h), (i) or (j), the other substituents are as defined in claim 1.
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