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1.发明授权TREATMENT OF HYPERPROLIFERATIVE DISEASE WITH SUPERANTIGEN IN COMBINATION WITH A CYTOSTATIC AGENT 有权治疗与超抗原合用过度增生性疾病具有中等抑制细胞生长。
公开(公告)号：EP1786449B1
公开(公告)日：2015-07-01
申请号：EP05777870.6
申请日：2005-08-12
申请人： Active Biotech AB
CPC分类号： A61K39/00 , A61K31/7072 , A61K33/24 , A61K38/00 , A61K39/0005 , A61K39/0011 , A61K45/06 , A61K47/6811 , A61K47/6851 , C07K14/31 , C07K2319/30 , C07K2319/33 , A61K2300/00
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2.发明公开TREATMENT OF HYPERPROLIFERATIVE DISEASE WITH SUPERANTIGENS IN COMBINATION WITH ANOTHER ANTICANCER AGENT 有权治疗与超抗原合用过度增生性疾病具有中等抑制细胞生长。
公开(公告)号：EP1786449A2
公开(公告)日：2007-05-23
申请号：EP05777870.6
申请日：2005-08-12
申请人： Active Biotech AB
CPC分类号： A61K39/00 , A61K31/7072 , A61K33/24 , A61K38/00 , A61K39/0005 , A61K39/0011 , A61K45/06 , A61K47/6811 , A61K47/6851 , C07K14/31 , C07K2319/30 , C07K2319/33 , A61K2300/00
摘要： The present invention relates to methods of treating mammals affected by, for example, a hyperproliferative disease such as cancer, by administering a tumor-targeted superantigen and a chemotherapeutic agent, whereby the administration of the tumor-targeted superantigen and chemotherapeutic agent reduce the antibody response and enhance the T cell response. The superantigen, wild-type or modified, is fused to a target-seeking moiety, such as an antibody or an antibody active fragment. The combined administration of a superantigen and a chemotherapeutic agent provides enhanced therapeutic effects in a treated animal.
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