公开(公告)号：EP3362478A1

公开(公告)日：2018-08-22

申请号：EP16791328.4

申请日：2016-10-13

申请人： Affimed GmbH

发明人： ELLWANGER, Kristina ,  FUCEK, Ivica ,  ROSS, Thorsten ,  MUELLER, Thomas ,  RAJKOVIC, Erich ,  REUSCH, Uwe ,  TREDER, Martin ,  WEICHEL, Michael

IPC分类号： C07K16/28

CPC分类号： C07K16/2803 ,  C07K16/283 ,  C07K16/2878 ,  C07K2317/31 ,  C07K2317/35 ,  C07K2317/62 ,  C07K2317/626

摘要： Described is a trispecific antibody molecule comprising a diabody-unit integrated into a polypeptide chain having at least six variable domains linked one after another. In certain instances two single-chain Fv (scFv) fragments are distally connected to the diabody-unit providing two further antigen binding sites (Figs. 1 and 2).