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1.
公开(公告)号:EP2185574A2
公开(公告)日:2010-05-19
申请号:EP08799268.1
申请日:2008-09-05
申请人: Agensys, Inc.
发明人: RAITANO, Arthur, B. , MORRISON, Robert, Rendall , MORRISON, Karen Jane, Mayrick , KANMER, Steven, B. , CHALLITA-EID, Pia, M. , JIA, Xiao-chi , GUDAS, Jean , JAKOBOVITS, Aya
IPC分类号: C07H21/02 , A61K31/713
CPC分类号: G01N33/57484 , A01K2267/0331 , A61K51/1045 , C07K16/30 , C07K16/3015 , C07K16/303 , C07K16/3046 , C07K2317/56 , C07K2317/732 , C07K2317/77 , G01N2500/00
摘要: Antibodies and molecules derived therefrom that bind to 24P4C12 protein and variants thereof, are described wherein 24P4C12 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 24P4C12 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 24P4C12 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 24P4C12 can be used in active or passive immunization.
摘要翻译: 描述了结合24P4C12蛋白及其变体的由其衍生的抗体和分子,其中24P4C12在正常成人组织中表现出组织特异性表达,并在表I中列出的癌症中异常表达。因此,24P4C12提供了诊断,预后,预防和 /或癌症的治疗靶标。 24P4C12基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与24P4C12反应的抗体或T细胞可用于主动或被动免疫。
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2.
公开(公告)号:EP2185574B1
公开(公告)日:2013-05-08
申请号:EP08799268.1
申请日:2008-09-05
申请人: Agensys, Inc.
发明人: RAITANO, Arthur, B. , MORRISON, Robert, Rendall , MORRISON, Karen Jane, Mayrick , KANMER, Steven, B. , CHALLITA-EID, Pia, M. , JIA, Xiao-chi , GUDAS, Jean , JAKOBOVITS, Aya
IPC分类号: C07K16/30 , C07H21/02 , A61K31/713 , G01N33/574
CPC分类号: G01N33/57484 , A01K2267/0331 , A61K51/1045 , C07K16/30 , C07K16/3015 , C07K16/303 , C07K16/3046 , C07K2317/56 , C07K2317/732 , C07K2317/77 , G01N2500/00
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