公开(公告)号：EP3344656A1

公开(公告)日：2018-07-11

申请号：EP16763697.6

申请日：2016-09-01

申请人： Agenus Inc. ,  Ludwig Institute for Cancer Research Ltd ,  Memorial Sloan Kettering Cancer Center

发明人： VAN DIJK, Marc ,  MUNDT, Cornelia, Anne ,  RITTER, Gert ,  WOLCHOK, Jedd, David ,  MERGHOUB, Taha ,  ZAPPASODI, Roberta ,  HOLMGAARD, Rikke, Bæk ,  SCHAER, David ,  SAVITSKY, David, Adam ,  WILSON, Nicholas, Stuart

IPC分类号： C07K16/28 ,  A61K39/00

CPC分类号： C07K16/2818 ,  A61K2039/507 ,  C07K16/2803 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/52 ,  C07K2317/565 ,  C07K2317/71 ,  C07K2317/72 ,  C07K2317/76 ,  C07K2317/92

摘要： The instant disclosure provides antibodies that specifically bind to human PD-1 and antagonize PD-1 function. Also provided are pharmaceutical compositions comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies.