公开(公告)号：EP0467435A3

公开(公告)日：1992-04-01

申请号：EP91201572.4

申请日：1991-06-20

申请人： Akzo Nobel N.V.

发明人： Uilenstede, Patricia Caldirola ,  Mannhold, Raimund ,  Timmerman, Hendrik

IPC分类号： C07C217/10 ,  C07C323/25

CPC分类号： C07C211/28 ,  C07C211/27 ,  C07C217/10 ,  C07C323/25

摘要： The invention relates to a benzhydryl derivative having the formula
wherein each of the groups Ri, R 2 , and R 3 represents one to four substituents independently selected from the group consisting of hydrogen, lower alkyl, halogen, and CF 3 , and at least one of the groups Ri, R 2 , and R 3 is halogen or CF 3 ;
R 4 represents hydrogen or methyl; n is 2, 3, or 4; m is 1, 2, or 3; and X represents O or S; or its pharmaceutically acceptable salts. The benzhydryl derivative of the invention can be used to treat patients who are suffering from diseases which are influenced by calmodulin.

公开(公告)号：EP0467435A2

公开(公告)日：1992-01-22

申请号：EP91201572.4

申请日：1991-06-20

申请人： Akzo Nobel N.V.

发明人： Uilenstede, Patricia Caldirola ,  Mannhold, Raimund ,  Timmerman, Hendrik

IPC分类号： C07C217/10 ,  C07C323/25

CPC分类号： C07C211/28 ,  C07C211/27 ,  C07C217/10 ,  C07C323/25

摘要： The invention relates to a benzhydryl derivative having the formula
wherein each of the groups Ri, R 2 , and R 3 represents one to four substituents independently selected from the group consisting of hydrogen, lower alkyl, halogen, and CF 3 , and at least one of the groups Ri, R 2 , and R 3 is halogen or CF 3 ;

R 4 represents hydrogen or methyl;
n is 2, 3, or 4;
m is 1, 2, or 3; and
X represents O or S;
or its pharmaceutically acceptable salts.

The benzhydryl derivative of the invention can be used to treat patients who are suffering from diseases which are influenced by calmodulin.

摘要翻译： 本发明涉及具有式CHEM的二苯甲基衍生物，其中R1，R2和R3各自表示1-4个独立地选自氢，低级烷基，卤素和CF 3的取代基，和至少一个 基团R 1，R 2和R 3是卤素或CF 3; R4代表氢或甲基; n为2,3或4; m为1,2或3; X表示O或S; 或其药学上可接受的盐。 本发明的二苯甲基衍生物可用于治疗患有受钙调素影响的疾病的患者。