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公开(公告)号：EP0888551A1
公开(公告)日：1999-01-07
申请号：EP97908256.0
申请日：1997-03-17
申请人： Akzo Nobel N.V.
CPC分类号： C07K16/082
摘要： The present invention is concerned with prognosis of the development of Hepatitis B infection. The method according to the invention may also be used to monitor antiviral therapy with, for example, antiviral compounds like alpha-interferon. The present invention is based on the finding that the presence of specific biomolecules able to form complexes with HBeAg is a prognostic marker for the further development of an acute Hepatitis B infection. It has been found that based on the presence or absence of said specific biomolecules or complexes of said biomolecules and HBeAg during the acute phase of infection it can be predicted whether patients will recover and clear the virus after acute infection or will develop a chronic infection. The present invention therefore involves the use of an assay for the detection of circulating complexes comprising specific biomolecules bound to HBeAg in a method for predicting the course of infection in patients with an acute HBV infection. The present invention provides a new method for the prognosis of the development of Hepatitis B infection which can also be used to monitor therapy with antiviral agents and to indicate what the effect of such therapy is.
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2.发明公开ANTIBODIES AND OTHER BINDING MOLECULES SPECIFIC FOR HEPATITIS B VIRAL ANTIGENS 失效抗体和其他结合分子的抗乙型肝炎病毒抗原
公开(公告)号：EP0993470A2
公开(公告)日：2000-04-19
申请号：EP98937559.7
申请日：1998-06-22
申请人： Akzo Nobel N.V.
IPC分类号： C07K16/08 , C12N5/20 , C07K14/02 , G01N33/569 , G01N33/577
CPC分类号： C07K14/005 , C07K16/082 , C07K2317/34 , C12N2730/10122 , Y10S436/82
摘要： The present invention relates to antibodies and other binding molecules specific for hepatitis B viral antigens (HBV), peptides comprising epitopes recognised by such molecules, and cell lines capable of producing antibodies. The invention is further concerned with the use of such molecules in diagnosis of hepatitis B virus (HBV). The invention further relates to a method for the diagnosis of hepatitis B, the method comprising contacting the sample suspected to contain hepatitis B particles or antigens with the specific binding molecule according to the invention. More preferred, the invention relates to a method for the diagnosis of hepatitis B, the method comprising contacting the sample suspected to contain hepatitis B particles or antigens with at least one specific binding molecule directed to the S-region of HBV and at least one specific binding molecule according to the present invention. The invention further relates to an assay kit for the detection of a hepatitis B particle or antigen, the kit comprising a specific binding molecule according to the invention and means for detecting whether the specific binding molecule is bound to a hepatitis B particle or antigen.
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