公开(公告)号：EP2646468A2

公开(公告)日：2013-10-09

申请号：EP11844615.2

申请日：2011-12-01

申请人： Alder Biopharmaceuticals, Inc.

发明人： DUTZAR, Benjamin H. ,  KOVACEVICH, Brian R. ,  MITCHELL, Danielle M. ,  OJALA, Ethan W. ,  FAN, Pei ,  SMITH, Jeffrey T.L. ,  MCNEILL, Patricia Dianne ,  BILLGREN, Jens ,  STEWART, Erica A. ,  AKATSUKA, Corinne C. ,  CHANG, Betty Yu-Ching ,  LATHAM, John A. ,  GARCIA-MARTINEZ, Leon F.

IPC分类号： C07K16/22 ,  C12N15/13 ,  A61K39/395 ,  G01N33/53 ,  A61P35/00

CPC分类号： C07K16/22 ,  A61K39/3955 ,  A61K45/06 ,  A61K51/1021 ,  A61K2039/505 ,  C07K16/2875 ,  C07K2317/24 ,  C07K2317/41 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94 ,  Y02A50/466

摘要： NGF antagonists including antibodies and antibody fragments thereof having binding specificity to human Nerve Growth Factor (“NGF”), and methods of treating pain. Methods of treating pain or eliciting an analgesic effect in an individual comprising administering an effective amount of an NGF antagonist inhibits the association of NGF with TrkA without inhibiting the association of NGF with p75. The methods may further comprise administering an effective amount of a second anti-human NGF antibody or fragment thereof which inhibits the association of NGF with p75, that may further also inhibit the association of NGF with TrkA.

摘要翻译： 包括对人类神经生长因子（“NGF”）具有结合特异性的抗体及其抗体片段的NGF拮抗剂和治疗疼痛的方法。 治疗疼痛或在个体中引起镇痛作用的方法包括给予有效量的NGF拮抗剂抑制NGF与TrkA的结合，而不抑制NGF与p75的结合。 所述方法还可包括施用有效量的抑制NGF与p75缔合的第二抗人NGF抗体或其片段，其还可以抑制NGF与TrkA的缔合。