公开(公告)号：EP1926705B3

公开(公告)日：2010-09-15

申请号：EP06832282.5

申请日：2006-06-29

申请人： Alembic Limited

发明人： SONI, Rohit, Ravikant ,  VASOYA, Sanjay, Lakhabhai ,  GHOTIKAR, Ravindra, Charudatta ,  PANDEY, Anand, Kumar ,  SHAH, Hetal, Remeshchandra

IPC分类号： C07C255/58 ,  C07C253/34 ,  A61K31/395 ,  C07D257/04

CPC分类号： C07D257/04 ,  C07C255/58

摘要： The invention relates to novel compound of formula (IV), which is an organic acid salt of N-[(2'-cyanobiphenyl-4-yl)methyl]-(L)-valine ester. This compound is an useful intermediate for process of preparation of Valsartan of formula (I), chemically known as (S)-N-(l-Carboxy-2-methylprop-l-yl)-N-pentanoyl-N-[2'-(lH-tetrazol-5-yl)biphenyl-4- ylmethyl]amine. This invention also relates to a process for preparing Valsartan using novel intermediate of formula (IV).

公开(公告)号：EP1926705B1

公开(公告)日：2009-09-02

申请号：EP06832282.5

申请日：2006-06-29

申请人： Alembic Limited

发明人： SONI, Rohit, Ravikant ,  VASOYA, Sanjay, Lakhabhai ,  GHOTIKAR, Ravindra, Charudatta ,  PANDEY, Anand, Kumar ,  SHAH, Hetal, Remeshchandra

IPC分类号： C07C255/58 ,  C07C253/34 ,  A61K31/395 ,  C07D257/04

CPC分类号： C07D257/04 ,  C07C255/58

摘要： The invention relates to novel compound of formula (IV), which is an organic acid salt of N-[(2'-cyanobiphenyl-4-yl)methyl]-(L)-valine ester. This compound is an useful intermediate for process of preparation of Valsartan of formula (I), chemically known as (S)-N-(l-Carboxy-2-methylprop-l-yl)-N-pentanoyl-N-[2'-(lH-tetrazol-5-yl)biphenyl-4- ylmethyl]amine. This invention also relates to a process for preparing Valsartan using novel intermediate of formula (IV).

公开(公告)号：EP1926705A2

公开(公告)日：2008-06-04

申请号：EP06832282.5

申请日：2006-06-29

申请人： Alembic Limited

发明人： SONI, Rohit, Ravikant ,  VASOYA, Sanjay, Lakhabhai ,  GHOTIKAR, Ravindra, Charudatta ,  PANDEY, Anand, Kumar ,  SHAH, Hetal, Remeshchandra

IPC分类号： C07C255/58 ,  C07C253/34 ,  A61K31/395 ,  C07D257/04

CPC分类号： C07D257/04 ,  C07C255/58

摘要： The invention relates to novel compound of formula (IV), which is an organic acid salt of N-[(2'-cyanobiphenyl-4-yl)methyl]-(L)-valine ester. This compound is an useful intermediate for process of preparation of Valsartan of formula (I), chemically known as (S)-N-(l-Carboxy-2-methylprop-l-yl)-N-pentanoyl-N-[2'-(lH-tetrazol-5-yl)biphenyl-4- ylmethyl]amine. This invention also relates to a process for preparing Valsartan using novel intermediate of formula (IV).