公开(公告)号：EP1628664A2

公开(公告)日：2006-03-01

申请号：EP04754164.4

申请日：2004-06-03

申请人： Alkermes Controlled Therapeutics, Inc. II

发明人： BRITTAIN, Harry, A. ,  DICKASON, David, A. ,  HOTZ, Joyce ,  LYONS, Shawn, L. ,  RAMSTACK, Michael, J. ,  WRIGHT, Steven, G.

IPC分类号： A61K31/485

CPC分类号： A61K31/485 ,  C07B2200/13 ,  C07C19/03 ,  C07D489/06 ,  C07D489/08

摘要： This invention relates to the discovery of novel polymorphic forms of naltrexone, including solvates, hydrates, anhydrous and other crystalline forms and combinations thereof. These novel forms of naltrexone impart advantages in pharmaceutical formulations incorporating them, including sustained release, or long acting, formulations.