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公开(公告)号：EP3083625B1
公开(公告)日：2017-11-01
申请号：EP14815843.9
申请日：2014-12-19
发明人： HARRISON, Timothy , TREVITT, Graham , HEWITT, Peter Robin , O'DOWD, Colin Roderick , BURKAMP, Frank , WILKINSON, Andrew John , SHEPHERD, Steven D. , MIEL, Hugues
IPC分类号： C07D487/04 , C07D519/00 , A61K31/519 , A61P35/00 , C07D487/14
CPC分类号： C07D487/04 , C07D475/00 , C07D487/14 , C07D519/00
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公开(公告)号：EP3083625A1
公开(公告)日：2016-10-26
申请号：EP14815843.9
申请日：2014-12-19
发明人： HARRISON, Timothy , TREVITT, Graham , HEWITT, Peter Robin , O'DOWD, Colin Roderick , BURKAMP, Frank , WILKINSON, Andrew John , SHEPHERD, Steven D. , MIEL, Hugues
IPC分类号： C07D487/04 , C07D519/00 , A61K31/519 , A61P35/00 , C07D487/14
CPC分类号： C07D487/04 , C07D475/00 , C07D487/14 , C07D519/00
摘要： The present invention relates to compounds that are useful as inhibitors of the activity of Wee-1 kinase. The present invention also relates to pharmaceutical compositions comprising these compounds and to methods of using these compounds in the treatment of cancer and methods of treating cancer.
摘要翻译： 本发明涉及用作Wee-1激酶活性抑制剂的化合物。 本发明还涉及包含这些化合物的药物组合物以及使用这些化合物治疗癌症的方法和治疗癌症的方法。
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3.发明授权6-(4-(1-AMINO-3-HYDROXYCYCLOBUTYL)PHENYL)-5-PHENYL(FURO, THIENO OR PYRROLO)[2,3-D]PYRIMIDIN-4-ONE DERIVATIVES FOR THE TREATMENT OF CANCER 有权6-（4-（1-氨基-3-羟基环丁基）苯基）-5-苯基（呋喃并，噻吩并吡咯并OR）[2,3-d]嘧啶-4-酮衍生物用于癌症的治疗
公开(公告)号：EP2838901B1
公开(公告)日：2016-11-02
申请号：EP13721018.3
申请日：2013-03-25
发明人： HARRISON, Timothy , O'DOWD, Colin , SHEPHERD, Steven , TREVITT, Graham , ZHANG, Lixin , BURKAMP, Frank
IPC分类号： C07D491/048 , C07D495/04 , C07D487/04 , A61K31/519 , A61P31/00
CPC分类号： C07D495/04 , C07D487/04 , C07D491/048
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4.发明公开6- (4- (1 -AMINO- 3 -HYDROXYCYCLOBUTYL) PHENYL) - 5 - PHENYL (FURO, THIENO OR PYRROLO) [2, 3-D]PYRIMIDIN- 4 - ONE DERIVATIVES FOR THE TREATMENT OF CANCER 有权6-（4-（1-氨基-3-羟基环丁基）苯基）-5-苯基（呋喃并，噻吩并吡咯并OR）[2,3-d]嘧啶-4-酮衍生物用于癌症的治疗
公开(公告)号：EP2838901A1
公开(公告)日：2015-02-25
申请号：EP13721018.3
申请日：2013-03-25
发明人： HARRISON, Timothy , O'DOWD, Colin , SHEPHERD, Steven , TREVITT, Graham , ZHANG, Lixin , BURKAMP, Frank
IPC分类号： C07D491/048 , C07D495/04 , C07D487/04 , A61K31/519 , A61P31/00
CPC分类号： C07D495/04 , C07D487/04 , C07D491/048
摘要： The present invention relates to compounds of Formula (I) that are useful as inhibitors of the activity of one or more isoforms of the serine / threonine kinase AKT. The present invention also relates to pharmaceutical compositions comprising these compounds and to methods of using these compounds in the treatment of cancer and methods of treating cancer.
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