公开(公告)号：EP2575764B1

公开(公告)日：2017-04-19

申请号：EP11726579.3

申请日：2011-06-03

申请人： Alnylam Pharmaceuticals, Inc.

发明人： MANOHARAN, Muthiah ,  MAIER, Martin ,  JAYARAMAN, Muthusamy ,  MATSUDA, Shigeo ,  JAYAPRAKASH, Narayanannair, K. ,  RAJEEV, Kallanthottathil, G. ,  AKINC, Akin ,  BAILLIE, Thomas, A.

IPC分类号： A61K31/713 ,  C07C229/12 ,  C12N15/113 ,  C12N15/88 ,  A61K39/00 ,  A61K47/44

CPC分类号： C07C229/12 ,  A61K31/713 ,  A61K39/0005 ,  A61K47/44 ,  C12N15/113 ,  C12N15/88 ,  C12N2310/14 ,  C12N2320/30

公开(公告)号：EP2575764A2

公开(公告)日：2013-04-10

申请号：EP11726579.3

申请日：2011-06-03

申请人： Alnylam Pharmaceuticals, Inc.

发明人： MANOHARAN, Muthiah ,  MAIER, Martin ,  JAYARAMAN, Muthusamy ,  MATSUDA, Shigeo ,  JAYAPRAKASH, Narayanannair, K. ,  RAJEEV, Kallanthottathil, G. ,  AKINC, Akin ,  BAILLIE, Thomas, A.

IPC分类号： A61K9/10 ,  A61K39/00 ,  A61K48/00 ,  C07C69/02 ,  C07C211/62 ,  C07C211/63 ,  C12N15/87 ,  A61K47/48

CPC分类号： C07C229/12 ,  A61K31/713 ,  A61K39/0005 ,  A61K47/44 ,  C12N15/113 ,  C12N15/88 ,  C12N2310/14 ,  C12N2320/30

摘要： The present invention relates to a cationic lipid having one or more biodegradable groups located in the mid- or distal section of a lipidic moiety (e.g., a hydrophobic chain) of the cationic lipid. These cationic lipids may be incorporated into a lipid particle for delivering an active agent, such as a nucleic acid. The invention also relates to lipid particles comprising a neutral lipid, a lipid capable of reducing aggregation, a cationic lipid of the present invention, and optionally, a sterol. The lipid particle may further include a therapeutic agent such as a nucleic acid.