公开(公告)号：EP2440183A1

公开(公告)日：2012-04-18

申请号：EP10786869.7

申请日：2010-06-10

申请人： Alnylam Pharmaceuticals, Inc.

发明人： AKINC, Akin ,  DORKIN, Joseph, R. ,  QIN, Xiaojun ,  CANTLEY, William ,  MANOHARAN, Muthiah ,  RAJEEV, Kallanthottathil, G. ,  NARAYANANNAIR, Jayaprakash, K. ,  JAYARAMAN, Muthusamy ,  CHEN, Jianxin ,  ANSELL, Steven

IPC分类号： A61K9/127 ,  C07C211/00 ,  A61K31/20

CPC分类号： A61K9/1272 ,  A61K9/1278 ,  A61K31/22 ,  A61K31/7088 ,  A61K31/712 ,  A61K31/713 ,  A61K38/1709 ,  A61K38/4846 ,  A61K47/14 ,  A61K47/549 ,  A61K47/551 ,  A61K47/6911 ,  A61K48/0033 ,  C07C29/58 ,  C07C227/18 ,  C07C227/40 ,  C07C229/12 ,  C07D475/04 ,  C12N15/113 ,  C12N15/1137 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/322 ,  C12N2310/341 ,  C12N2310/346 ,  C12N2310/351 ,  C12N2310/3515 ,  C12N2320/32 ,  Y02A50/463 ,  A61K2300/00 ,  C12N2310/3521 ,  C12N2310/3533

摘要： The invention features a cationic lipid of formula I, an improved lipid formulation comprising a cationic lipid of formula I and corresponding methods of use. Also disclosed are targeting lipids, and specific lipid formulations comprising such targeting lipids.

公开(公告)号：EP3969052A1

公开(公告)日：2022-03-23

申请号：EP20731644.9

申请日：2020-05-15

申请人： Alnylam Pharmaceuticals Inc.

发明人： NAIR, Jayaprakash K. ,  QIN, Xiaojun ,  YU, Mikyung ,  JADHAV, Vasant ,  MAIER, Martin ,  RAMSDEN, Diane

IPC分类号： A61K47/12 ,  A61K31/713 ,  C12N15/113 ,  A61K47/18 ,  A61K47/54

公开(公告)号：EP2391343A2

公开(公告)日：2011-12-07

申请号：EP10703734.3

申请日：2010-01-29

申请人： Alnylam Pharmaceuticals Inc.

发明人： AKINC, Akin ,  QUERBES, William ,  WONG, Frances ,  DORKIN, Joseph, Robert ,  QIN, Xiaojun ,  CANTLEY, William ,  BORODOVSKY, Anna ,  DE, Soma ,  MANOHARAN, Muthiah ,  JAYARAMAN, Muthusamy ,  RAJEEV, Kallanthottathil, G.

IPC分类号： A61K9/127 ,  A61K48/00

CPC分类号： A61K48/0008 ,  A61K9/1272

摘要： The invention features an improved lipid formulation comprising a cationic lipid of formula (A), a neutral lipid, a sterol and a PEG or PEG-modified lipid, where R
1 and R
2 are independently alkyl, alkenyl or alkynyl, each can be optionally substituted, and R
3 and R
4 are independently lower alkyl or R
3 and R
4 can be taken together to form an optionally subsituted heterocyclic ring. In one embodiment, R
1 and R
2 are independently selected from oleoyl, pamitoyl, steroyl, linoleyl and R
3 and R
4 are methyl. Also disclosed are targeting lipids, and specific lipid formulations comprising such targeting lipids.