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1.发明公开
公开(公告)号：EP3052628A1
公开(公告)日：2016-08-10
申请号：EP14800179.5
申请日：2014-10-03
发明人： BETTENCOURT, Brian , FITZGERALD, Kevin , QUERBES, William , DESNICK, Robert, J. , YASUDA, Makiko
IPC分类号： C12N15/113 , A61K31/7088 , A61K31/713 , A61P3/00
摘要： The invention relates to double-stranded ribonucleic acid (dsRNA) compositions targeting the ALAS1 gene, and methods of using such dsRNA compositions to alter (e.g., inhibit) expression of ALAS1.
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公开(公告)号：EP3284824A1
公开(公告)日：2018-02-21
申请号：EP17175148.0
申请日：2013-04-10
发明人： BETTENCOURT, Brian , FITZGERALD, Kevin , QUERBES, William , YASUDA, Makiko , DESNICK, Robert J.
IPC分类号： C12N15/113 , A61K31/713
CPC分类号： C12N15/113 , A61K31/713 , C12N15/1137 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/343 , C12N2310/344 , C12N2310/351 , C12N2310/3521 , C12N2310/3533 , C12N2310/50 , C12N2310/533 , C12N2320/30 , C12Y203/01037
摘要： The invention relates to double-stranded ribonucleic acid (dsRNA) compositions targeting the ALAS1 gene, and methods of using such dsRNA compositions to alter (e.g., inhibit) expression of ALAS1.
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公开(公告)号：EP2836595B1
公开(公告)日：2017-06-14
申请号：EP13721433.4
申请日：2013-04-10
发明人： BETTENCOURT, Brian , FITZGERALD, Kevin , QUERBES, William , YASUDA, Makiko , DESNICK, Robert, J.
IPC分类号： C12N15/113 , A61K31/713 , A61P43/00
CPC分类号： C12N15/113 , A61K31/713 , C12N15/1137 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/343 , C12N2310/344 , C12N2310/351 , C12N2310/3521 , C12N2310/3533 , C12N2310/50 , C12N2310/533 , C12N2320/30 , C12Y203/01037
摘要： The invention relates to double-stranded ribonucleic acid (dsRNA) compositions targeting the ALAS1 gene, and methods of using such dsRNA compositions to alter (e.g., inhibit) expression of ALAS1.
摘要翻译： 本发明涉及靶向ALAS1基因的双链核糖核酸（dsRNA）组合物，以及使用这种dsRNA组合物改变（例如抑制）ALAS1表达的方法。
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公开(公告)号：EP3868883A1
公开(公告)日：2021-08-25
申请号：EP21155819.2
申请日：2013-04-10
发明人： BETTENCOURT, Brian , FITZGERALD, Kevin , QUERBES, William , YASUDA, Makiko , DESNICK, Robert J.
IPC分类号： C12N15/113 , A61K31/713
摘要： The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting expression of ALAS1, wherein the dsRNA comprises a sense strand and an antisense strand, the antisense strand comprising a region of complementarity to an ALAS1 transcript, which antisense strand comprises at least 15 contiguous nucleotides differing by no more than 3 nucleotides from the antisense sequence of SEQ ID NO: 3553.
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公开(公告)号：EP3052628B1
公开(公告)日：2020-02-26
申请号：EP14800179.5
申请日：2014-10-03
发明人： BETTENCOURT, Brian , FITZGERALD, Kevin , QUERBES, William , DESNICK, Robert, J. , YASUDA, Makiko
IPC分类号： C12N15/113 , A61K31/7088 , A61K31/713 , A61P3/00
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公开(公告)号：EP2836595A2
公开(公告)日：2015-02-18
申请号：EP13721433.4
申请日：2013-04-10
发明人： BETTENCOURT, Brian , FITZGERALD, Kevin , QUERBES, William , YASUDA, Makiko , DESNICK, Robert, J.
IPC分类号： C12N15/113 , A61K31/713 , A61P43/00
CPC分类号： C12N15/113 , A61K31/713 , C12N15/1137 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/343 , C12N2310/344 , C12N2310/351 , C12N2310/3521 , C12N2310/3533 , C12N2310/50 , C12N2310/533 , C12N2320/30 , C12Y203/01037
摘要： The invention relates to double-stranded ribonucleic acid (dsRNA) compositions targeting the ALAS1 gene, and methods of using such dsRNA compositions to alter (e.g., inhibit) expression of ALAS1.
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