公开(公告)号：EP1635763A2

公开(公告)日：2006-03-22

申请号：EP04776396.6

申请日：2004-06-09

申请人： Alnylam Pharmaceuticals Inc.

发明人： MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH ,  BUMCROT, David ,  FARRER, Matthew, J. ,  MARAGANORE, Demetrius ,  VORNLOCHER, Hans-Peter

IPC分类号： A61K6/00

CPC分类号： C12N15/113 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3517 ,  C12N2310/3521

摘要： Aspects featured in the invention relate to compositions and methods for inhibiting alpha-synuclein (SNCA) gene expression, such as for the treatment of neurodegenerative disorders. An anti- SNCA agent featured herein that targets the SNCA gene can have been modified to alter distribution in favor of neural cells.