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    ALPHAVIRUS REPLICON PARTICLES EXPRESSING TRP2
    1.
    发明公开
    ALPHAVIRUS REPLICON PARTICLES EXPRESSING TRP2 有权
    TRP2表达甲病毒复制子颗粒

    公开(公告)号：EP2416662A1

    公开(公告)日：2012-02-15

    申请号：EP10762452.0

    申请日：2010-04-08

    申请人： Alphavax, Inc. ,  Sloan-Kettering Institute for Cancer Research

    发明人： WOLCHOK, Jedd D. ,  AVOGADRI, Francesca ,  OLMSTED, Robert A. ,  MAUGHAN, Maureen

    IPC分类号： A01N63/00 ,  A61K39/12

    CPC分类号： A61K39/0011 ,  A61K2039/5254 ,  A61K2039/5256

    摘要： The immune response to melanoma cells and tumors can be induced or significantly increased by administering to a subject a pharmaceutical composition comprising alphavirus particles, especially Venezuelan equine encephalitis virus replicon particles, which express the melanoma antigen dopachrome tautomerase (DCT, TRP2) in cells of the subject, with the result of tumor regression and /or inhibition of metastasis of a melanoma subject, or a decreased risk of the occurrence or recurrence of melanoma and/or decreased severity of melanoma in a subject not suffering from melanoma at the time of administration. The pharmaceutical composition described herein can be used in conjunction with other therapeutic agents, it can be administered on more than one occasion and it can be combined with administrations of other compositions such as protein or other immunogenic compositions, and/or adjuvants, with beneficial effects to the human or animal subject to which it has been administered.

    PROMOTERLESS CASSETTES FOR EXPRESSION OF ALPHAVIRUS STRUCTURAL PROTEINS
    2.
    发明公开
    PROMOTERLESS CASSETTES FOR EXPRESSION OF ALPHAVIRUS STRUCTURAL PROTEINS 有权
    促销代谢表达表达ZUR表达STRUKTURELLER ALPAHVIRUS-PROTEINE

    公开(公告)号：EP2947149A1

    公开(公告)日：2015-11-25

    申请号：EP15173487.8

    申请日：2008-06-20

    申请人： Alphavax, Inc.

    发明人： KAMRUD, Kurt I. ,  SMITH, Jonathan F. ,  MAUGHAN, Maureen

    IPC分类号： C12N15/63 ,  C12N15/40 ,  C07K14/705 ,  A61K38/00 ,  C12N15/86 ,  A61K39/12 ,  A61K39/00 ,  A61K39/285

    CPC分类号： C12N15/86 ,  A61K39/12 ,  A61K39/285 ,  A61K2039/5256 ,  C12N2710/24134 ,  C12N2770/36134 ,  C12N2770/36143

    摘要： The present invention provides use of an isolated RNA molecule comprising: a) an alphavirus 5' replication recognition sequence, wherein at least one initiation codon has been removed from the 5' replication recognition sequence; b) a nucleotide sequence encoding an alphavirus structural protein; and c) an alphavirus 3' replication recognition sequence, with the proviso that the RNA molecule does not contain a promoter that directs transcription of the nucleotide sequence of (b), and wherein the alphavirus 5' and 3' replication recognition sequences of (a) and (c) direct replication of the RNA molecule in the presence of alphavirus nonstructural proteins in inducing an immune response in a subject or for use in immunizing a subject or for treating a subject.

    摘要翻译： 本发明提供分离的RNA分子的用途，其包括：a）甲病毒5'复制识别序列，其中至少一个起始密码子已经从5'复制识别序列中除去; b）编码甲病毒结构蛋白的核苷酸序列; 和c）甲病毒3'复制识别序列，条件是RNA分子不含有指导（b）的核苷酸序列的转录的启动子，并且其中（a）的甲病毒5'和3'复制识别序列 ）和（c）在甲病毒非结构蛋白存在下RNA受体的直接复制以诱导受试者中的免疫应答或用于免疫受试者或用于治疗受试者。