公开(公告)号：EP2322228B1

公开(公告)日：2018-01-10

申请号：EP10182289.8

申请日：2001-06-05

申请人： Altor BioScience Corporation

发明人： Weidanz, Jon, A ,  Card, Kimberlyn, F ,  Wong, Hing, C

IPC分类号： C07K14/535 ,  C07K14/54 ,  C07K14/55 ,  C07K14/705 ,  A61K38/00 ,  C07K14/725

CPC分类号： C07K14/55 ,  A61K38/00 ,  A61K47/6425 ,  C07K14/535 ,  C07K14/5428 ,  C07K14/7051 ,  C07K2319/00 ,  C07K2319/30

摘要： Featured is T cell receptor complexes designed to redirect the immune system against various diseases. The T cell receptor complexes of the invention have been engineered to recognize target antigen in a functionally bispecific nature. Fusion protein complexes and protein conjugate complexes are comprised of high affinity antigen-specific TCR and biologically active proteins and/or effector molecules. Also featured are methods of production of T cell receptor fusion and conjugate complexes as well as therapeutic compositions for use of the complexes.

公开(公告)号：EP2322228A1

公开(公告)日：2011-05-18

申请号：EP10182289.8

申请日：2001-06-05

申请人： Altor BioScience Corporation

发明人： Weidanz, Jon, A ,  Card, Kimberlyn, F ,  Wong, Hing, C

IPC分类号： A61K47/48 ,  C07K14/535 ,  C07K14/54 ,  C07K14/55 ,  C07K14/705

CPC分类号： C07K14/55 ,  A61K38/00 ,  A61K47/6425 ,  C07K14/535 ,  C07K14/5428 ,  C07K14/7051 ,  C07K2319/00 ,  C07K2319/30

摘要： Featured is T cell receptor complexes designed to redirect the immune system against various diseases. The T cell receptor complexes of the invention have been engineered to recognize target antigen in a functionally bispecific nature. Fusion protein complexes and protein conjugate complexes are comprised of high affinity antigen-specific TCR and biologically active proteins and/or effector molecules. Also featured are methods of production of T cell receptor fusion and conjugate complexes as well as therapeutic compositions for use of the complexes.

摘要翻译： 特色是T细胞受体复合物设计用于重定向免疫系统针对各种疾病。 本发明的T细胞受体复合物已被工程化以识别功能上双特异性的靶抗原。 融合蛋白复合物和蛋白质缀合物复合物由高亲和力抗原特异性TCR和生物活性蛋白质和/或效应分子组成。 还特征在于生产T细胞受体融合物和缀合物复合物的方法以及用于复合物的治疗组合物。