专利检索 ap:("Alza Corporation") AND inv:"BHATTI, Gurdish" 第 1 页

1.

发明公开
DOSAGE FORMS FOR INCREASING THE SOLUBILITY AND EXTENDING THE RELEASE OF DRUGS SUCH AS E.G. TOPIRAMATE AND PHENYTON 审中-公开
标题翻译：方法和剂量形式溶解度增加等物质作为KONTROLIERTEN分布托吡酯和苯妥英

公开(公告)号：EP1517671A2

公开(公告)日：2005-03-30

申请号：EP03742204.5

申请日：2003-06-26

申请人： Alza Corporation

发明人： EDGREN, David , WONG, Patrick, S., L. , JAO, Frank , SKLUZACEK, Robert , LI, Shu , LAM, Andrew , BHATTI, Gurdish , LI, Shaoling , AYER, Atul , TO, Winnie

IPC分类号： A61K9/00 , A61K9/20 , A61K31/35 , A61K31/4166 , A61P25/08

CPC分类号： A61K31/4166 , A61K9/0004 , A61K31/35 , A61K47/34

摘要： Dosage forms and devices for enhancing controlled delivery of pharmaceutical agents by use of a drug core composition containing a polymer carrier (e.g. polyethylene oxide) and a surfactant (e.g. polyoxyl stearate, poloxamer) that increases the solubility of the pharmaceutical agent are described. The present invention provides a means of delivering high doses of lowly soluble drug in oral drug delivery systems that are convenient to swallow, for once-a-day administration. Osmotic devices are described.