专利检索 ap:("Alza Corporation, Inc.") AND inv:"EDGREN, David" 第 1 页

1.

发明公开
DRUG GRANULE COATINGS THAT IMPART SMEAR RESISTANCE DURING MECHANICAL COMPRESSION 审中-公开
标题翻译：药物颗粒涂料耐油性机械压缩奖

公开(公告)号：EP1701707A2

公开(公告)日：2006-09-20

申请号：EP04815921.4

申请日：2004-12-28

申请人： Alza Corporation, Inc.

发明人： EDGREN, David , KHAN, Alya , QURESHI, Abdul Majid , ERGUN, James , RAMACHANDRAN, Satishkumar , YAM, Noymi

IPC分类号： A61K9/20 , A61K9/50

CPC分类号： A61K9/0004 , A61K9/5026 , A61K9/5047

摘要： A drug formulation is disclosed comprising granules having a substrate and a coating, said granule substrate comprising a solubilizing surfactant or a low solubility therapeutic drug, or both, and said granule coating comprising a hydrophilic polymer. Also disclosed is a drug formulation consisting of a tablet core made by mechanical compression, wherein said tablet core comprises granules having a substrate and a coating, said granule substrate comprising a solubilizing surfactant or a low solubility therapeutic drug, or both, and said granule coating comprising a hydrophilic polymer. Also disclosed is a dosage form for oral administration of topiramate, comprising a tablet core and an osmotic delivery system. Methods for controlling topiramate release patterns by altering the composition of the topiramate dosage form are also disclosed.