公开(公告)号：EP1853288A2

公开(公告)日：2007-11-14

申请号：EP06719803.6

申请日：2006-01-27

申请人： Alza Corporation, Inc.

发明人： BENTZ, Hanne ,  HILL, Beth ,  LUCAS, Catherine ,  FREY, William, H.

IPC分类号： A61K38/00

CPC分类号： A61K38/34 ,  A61K9/0043 ,  A61K47/6811 ,  A61K51/08 ,  A61K51/086 ,  C07K2319/30

摘要： A method for delivering a polypeptide to the central nervous system of a mammal is provided. The method involves attaching the polypeptide to an antibody or an antibody fragment and administering the fusion polypeptide intranasally, for delivery to the central nervous system. Methods of treatment are also provided, where a therapeutically effective amount of the composition is delivered to the nasal cavity of a mammal.