公开(公告)号：EP1833831A1

公开(公告)日：2007-09-19

申请号：EP05855245.6

申请日：2005-12-20

申请人： Amgen Inc.

发明人： HONG, Fang-tsao ,  LIAO, Hongyu ,  LOPEZ, Patricia ,  TADESSE, Seifu ,  TAMAYO, Nuria A.

IPC分类号： C07D471/04 ,  C07D498/04 ,  A61K31/4375 ,  A61K31/5383 ,  A61P29/00

CPC分类号： C07D471/04

摘要： The present invention relates to nitrogen-containing compounds according to formula (I) and pharmaceutically acceptable salts thereof. Also included is a method of treatment of inflammation, rheumatoid arthritis, Pagets disease, osteoporosis, multiple myeloma, uveititis, acute or chronic myelogenous leukemia, pancreatic ß cell destruction, osteoarthritis, rheumatoid spondylitis, gouty arthritis, inflammatory bowel disease, adult respiratory distress syndrome (ARDS), psoriasis, Crohn's disease, allergic rhinitis, ulcerative colitis, anaphylaxis, contact dermatitis, asthma, muscle degeneration, cachexia, Reiter's syndrome, type I diabetes, type II diabetes, bone resorption diseases, graft vs. host reaction, Alzheimer's disease, stroke, myocardial infarction, ischemia reperfusion injury, atherosclerosis, brain trauma, multiple sclerosis, cerebral malaria, sepsis, septic shock, toxic shock syndrome, fever, myalgias due to HIV-1, HIV-2, HIV-3, cytomegalovirus (CMV), influenza, adenovirus, the herpes viruses or herpes zoster infection in a mammal comprising administering an effective amount a compound as described above.

公开(公告)号：EP2167504A2

公开(公告)日：2010-03-31

申请号：EP08780217.9

申请日：2008-07-16

申请人： Amgen, Inc

发明人： ALLEN, John, G. ,  BOURBEAU, Matthew, P. ,  DOMINGUEZ, Celia ,  FOTSCH, Christopher, H. ,  HAN, Nianhe ,  HONG, Fang-tsao ,  HUANG, Xin ,  LEE, Matthew, R. ,  LIU, Qingyian ,  REICHELT, Andreas ,  TADESSE, Seifu ,  WANG, Xianghong ,  YAO, Guomin ,  YUAN, Chester Chenguang ,  ZENG, Qingping

IPC分类号： C07D471/02 ,  C07D285/135 ,  C07D285/125 ,  A61K31/433 ,  A61P35/00 ,  A61P29/00

CPC分类号： C07D285/135 ,  C07D417/04 ,  C07D417/14 ,  C07D495/04

摘要： The invention relates to thiazole compounds of Formula I and Formula II and compositions thereof useful for treating diseases mediated by protein kinase B (PKB) where the variables have the definitions provided herein. The invention also relates to the therapeutic use of such thiazole compounds and compositions thereof in treating disease states associated with abnormal cell growth, cancer, inflammation, and metabolic disorders.

摘要翻译： 本发明涉及式I和式II的噻唑化合物及其组合物，其用于治疗由蛋白激酶B（PKB）介导的疾病，其中变量具有本文提供的定义。 本发明还涉及这种噻唑化合物及其组合物在治疗与异常细胞生长，癌症，炎症和代谢紊乱有关的疾病状态中的治疗用途。

公开(公告)号：EP2173728A2

公开(公告)日：2010-04-14

申请号：EP08794537.4

申请日：2008-07-16

申请人： Amgen Inc.

发明人： ZENG, Qingping ,  ZHANG, Dawei ,  YAO, Guomin ,  WOHLHIETER, George E. ,  WANG, Xianghong ,  RIDER, James ,  REICHELT, Andreas ,  MONENSCHEIN, Holger ,  HONG, Fang-tsao ,  FALSEY, James R. ,  DOMINGUEZ, Celia ,  BOURBEAU, Matthew P. ,  ALLEN, John G.

IPC分类号： C07D263/48 ,  C07D401/04 ,  C07D403/04 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  A61P35/00 ,  A61K31/5377 ,  A61K31/41

CPC分类号： C07D413/04 ,  C07D263/48 ,  C07D401/04 ,  C07D403/04 ,  C07D405/04 ,  C07D409/04 ,  C07D413/14 ,  C07D417/04

摘要： The invention relates to heterocyclic compounds of Formula I and compositions thereof useful for treating diseases mediated by protein kinase B (PKB) where the variables have the definitions provided herein Formula (I). The invention also relates to the therapeutic use of such compounds and compositions thereof in treating disease states associated with abnormal cell growth, cancer, inflammation, and metabolic disorders.