公开(公告)号：EP2445886A1

公开(公告)日：2012-05-02

申请号：EP10729753.3

申请日：2010-06-25

申请人： Amgen, Inc

发明人： CUSHING, Timothy D. ,  DRANSFIELD, Paul John ,  GONZALEZ LOPEZ DE TURISO, Felix ,  JOHNSON, Michael G. ,  KOHN, Todd J. ,  PATTAROPONG, Vatee ,  SIMARD, Jillian L.

IPC分类号： C07D215/44 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D407/14 ,  C07D409/12 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  A61K31/4706 ,  A61K31/4709 ,  A61P29/00

CPC分类号： C07D401/04 ,  C07D215/44 ,  C07D401/12 ,  C07D401/14 ,  C07D407/14 ,  C07D409/12 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04

摘要： Substituted bicyclic heteroaryls and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, including but not restricted to autoimmune diseases such as systemic lupus erythematosis (SLE), myestenia gravis, rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathic thrombocytopenic purpura, multiples sclerosis, Sjoegren's syndrome and autoimmune hemolytic anemia, allergic conditions including all forms of hypersensitivity, The present invention also enables methods for treating cancers that are mediated, dependent on or associated with p110 activity, including but not restricted to leukemias, such as Acute Myeloid leukaemia (AML) Myelo-dysplastic syndrome (MDS) myelo-proliferative diseases (MPD) Chronic Myeloid Leukemia (CML) T-cell Acute Lymphoblastic leukaemia ( T-ALL) B-cell Acute Lymphoblastic leukaemia (B-ALL) Non Hodgkins Lymphoma (NHL) B-cell lymphoma and solid tumors, such as breast cancer.

公开(公告)号：EP2635565A1

公开(公告)日：2013-09-11

申请号：EP11785857.1

申请日：2011-11-04

申请人： Amgen Inc.

发明人： FISHER, Benjamin ,  JOHNSON, Michael G. ,  LUCAS, Brian ,  SHIN, Youngsook ,  KAIZERMAN, Jacob

IPC分类号： C07D401/12 ,  C07D401/14 ,  C07D473/34 ,  C07D239/48 ,  C07D403/12 ,  A61K31/506 ,  A61K31/52 ,  A61K31/505 ,  A61P29/00 ,  A61P19/02 ,  A61P35/00 ,  A61P37/00

CPC分类号： C07D239/48 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D473/34

摘要： Substituted bicyclic heteroaryls and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, including but not restricted to autoimmune diseases such as systemic lupus erythematosis (SLE), myestenia gravis, rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathic thrombocytopenic purpura, multiples sclerosis, Sjoegren's syndrome and autoimmune hemolytic anemia, allergic conditions including all forms of hypersensitivity. The present invention also enables methods for treating cancers that are mediated, dependent on or associated with pi 105 activity, including but not restricted to leukemias, such as Acute Myeloid leukaemia (AML) Myelo-dysplastic syndrome (MDS) myelo-proliferative diseases (MPD) Chronic Myeloid Leukemia (CML) T-cell Acute Lymphoblastic leukaemia (T-ALL) B-cell Acute Lymphoblastic leukaemia (B-ALL) Non Hodgkins Lymphoma (NHL) B-cell lymphoma and solid tumors, such as breast cancer.

摘要翻译： 取代的双环杂芳基及其组合物，用于治疗一般炎症，关节炎，风湿性疾病，骨关节炎，炎性肠病，炎症性眼病，炎性或不稳定性膀胱病，牛皮癣，具有炎性成分的皮肤病，慢性炎症，包括但不限于 不限于系统性红斑狼疮（SLE），重症肌炎，类风湿性关节炎，急性播散性脑脊髓炎，特发性血小板减少性紫癜，多发性硬化症，舍约格综合征和自身免疫性溶血性贫血，包括所有形式的超敏反应的过敏性病症等自身免疫性疾病。 本发明还使得能够治疗依赖于或与p1105活性相关的癌症的方法，所述癌症包括但不限于白血病，例如急性髓细胞性白血病（AML）骨髓增生异常综合征（MDS）骨髓增生性疾病（MPD） ）慢性粒细胞白血病（CML）T细胞急性淋巴细胞白血病（T-ALL）B细胞急性淋巴细胞白血病（B-ALL）非霍奇金淋巴瘤（NHL）B细胞淋巴瘤和实体瘤，如乳腺癌。

公开(公告)号：EP2445886B1

公开(公告)日：2016-03-30

申请号：EP10729753.3

申请日：2010-06-25

申请人： Amgen, Inc

发明人： CUSHING, Timothy D. ,  DRANSFIELD, Paul John ,  GONZALEZ LOPEZ DE TURISO, Felix ,  JOHNSON, Michael G. ,  KOHN, Todd J. ,  PATTAROPONG, Vatee ,  SIMARD, Jillian L.

IPC分类号： C07D215/44 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D407/14 ,  C07D409/12 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  A61K31/4706 ,  A61K31/4709 ,  A61P29/00

CPC分类号： C07D401/04 ,  C07D215/44 ,  C07D401/12 ,  C07D401/14 ,  C07D407/14 ,  C07D409/12 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04

公开(公告)号：EP2445900B1

公开(公告)日：2016-03-02

申请号：EP10731874.3

申请日：2010-06-25

申请人： Amgen, Inc

发明人： BUI, Minna Hue Thanh ,  CHEN, Yi ,  CUSHING, Timothy D. ,  DUQUETTE, Jason A. ,  FISHER, Benjamin ,  GONZALEZ LOPEZ DE TURISO, Felix ,  HAO, Xiaolin ,  HE, Xiao ,  JOHNSON, Michael G. ,  LUCAS, Brian

IPC分类号： C07D401/12 ,  C07D401/14 ,  C07D471/04 ,  C07D487/04 ,  A61K31/4375 ,  A61K31/444 ,  A61P19/02

CPC分类号： C07D487/04 ,  C07D401/12 ,  C07D401/14 ,  C07D471/04 ,  C07D473/34

摘要： Substituted bicyclic heteroaryls and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, including but not restricted to autoimmune diseases such as systemic lupus erythematosis (SLE), myestenia gravis, rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathic thrombocytopenic purpura, multiples sclerosis, Sjoegren's syndrome and autoimmune hemolytic anemia, allergic conditions including all forms of hypersensitivity. The present invention also enables methods for treating cancers that are mediated, dependent on or associated with p110δ activity, including but not restricted to leukemias, such as Acute Myeloid leukaemia (AML) Myelo-dysplastic syndrome (MDS) myelo-proliferative diseases (MPD) Chronic Myeloid Leukemia (CML) T-cell Acute Lymphoblastic leukaemia (T-ALL) B-cell Acute Lymphoblastic leukaemia (B-ALL) Non Hodgkins Lymphoma (NHL) B-cell lymphoma and solid tumors, such as breast cancer.

公开(公告)号：EP2445900A2

公开(公告)日：2012-05-02

申请号：EP10731874.3

申请日：2010-06-25

申请人： Amgen, Inc

发明人： BUI, Minna Hue Thanh ,  CHEN, Yi ,  CUSHING, Timothy D. ,  DUQUETTE, Jason A. ,  FISHER, Benjamin ,  GONZALEZ LOPEZ DE TURISO, Felix ,  HAO, Xiaolin ,  HE, Xiao ,  JOHNSON, Michael G. ,  LUCAS, Brian

IPC分类号： C07D401/12 ,  C07D401/14 ,  C07D471/04 ,  C07D487/04 ,  A61K31/4375 ,  A61K31/444 ,  A61P19/02

CPC分类号： C07D487/04 ,  C07D401/12 ,  C07D401/14 ,  C07D471/04 ,  C07D473/34

摘要： Substituted bicyclic heteroaryls and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, including but not restricted to autoimmune diseases such as systemic lupus erythematosis (SLE), myestenia gravis, rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathic thrombocytopenic purpura, multiples sclerosis, Sjoegren's syndrome and autoimmune hemolytic anemia, allergic conditions including all forms of hypersensitivity. The present invention also enables methods for treating cancers that are mediated, dependent on or associated with p110δ activity, including but not restricted to leukemias, such as Acute Myeloid leukaemia (AML) Myelo-dysplastic syndrome (MDS) myelo-proliferative diseases (MPD) Chronic Myeloid Leukemia (CML) T-cell Acute Lymphoblastic leukaemia (T-ALL) B-cell Acute Lymphoblastic leukaemia (B-ALL) Non Hodgkins Lymphoma (NHL) B-cell lymphoma and solid tumors, such as breast cancer.