公开(公告)号：EP2336177A1

公开(公告)日：2011-06-22

申请号：EP10013141.6

申请日：2005-08-04

申请人： Amgen, Inc

发明人： Li, Ji ,  Shen, Wenyan ,  Lu, Hsieng Sen ,  Richards, William Gleason

IPC分类号： C07K16/18 ,  A61K39/395

CPC分类号： C07K16/18 ,  A61K2039/505 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92

摘要： The present invention provides antibodies and immunologically functional fragments thereof that specifically bind Dkk-1 polypeptides. The subject antibodies and fragments bind with high affinity to a conformational epitope located in the carboxy region of the Dkk-1 protein. Methods for preparing such antibodies or fragments thereof as well as physiologically acceptable compositions containing the antibodies or fragments are also provided. Use of the antibodies and fragments to treat various diseases including bone disorders, inflammatory diseases, neurological diseases, ocular diseases, renal diseases, pulmonary diseases and skin diseases are also disclosed.

摘要翻译： 本发明提供特异性结合Dkk-1多肽的抗体及其免疫功能片段。 受试抗体和片段以高亲和力结合位于Dkk-1蛋白的羧基区域的构象表位。 还提供了制备此类抗体或其片段的方法以及含有抗体或片段的生理上可接受的组合物。 还公开了使用抗体和片段来治疗各种疾病，包括骨病，炎性疾病，神经疾病，眼病，肾病，肺部疾病和皮肤疾病。